Epigenetic enzyme SMYD3 emerges as Achilles heel of gastric cancer DNA repair
New research reveals that the chromatin-modifying enzyme SMYD3 orchestrates DNA double-strand break repair in gastric cancer, and that blocking it ...
Tag: DNA damage response
Pancreatic Cancers With ATM Defects May Respond to Irinotecan, Study Finds
A new study combining real-world clinical data with CRISPR-edited cell models shows that pancreatic cancers with ATM or CHEK2 mutations ...
Deleting a Potassium Channel Rewires How Glioblastoma Cells Respond to FLASH-Style Radiation
Deleting the BKCa potassium channel alters oxidative stress, DNA damage signaling and repair gene expression in glioblastoma cells exposed to ...
Chemical Maps Expose Iron-Linked Enzyme as Hidden Guardian of Damaged DNA
A comprehensive chemogenomic map of the DNA damage response reveals that peroxiredoxin 1 safeguards cells against iron-driven oxidative DNA damage.
Scientists Reverse Radiotherapy Resistance in Lung Cancer by Rewiring the Immune Microenvironment
New research shows that lung tumors become radioresistant through ATR signaling activation and immune suppression, but innate immune agonists and ...
New 5-FU Derivative EB-18 Shows Potency Against Resistant Cancers
Researchers have engineered EB-18, a phosphonium-substituted derivative of the classic chemotherapy drug 5-fluorouracil that outperforms 5-FU and standard agents in ...
Cryo-EM Reveals How the ATR Checkpoint Kinase Flips Its Molecular Switch
New cryo-EM structures of human ATR–ATRIP in multiple functional states reveal how ATP priming, TopBP1 binding and autophosphorylation activate the ...
ATR Inhibitors Supercharge Bladder Cancer Chemotherapy in Patient-Derived Organoids
Dutch researchers have shown that combining the bladder chemotherapy drug mitomycin C with ATR kinase inhibitors eradicates patient-derived non-muscle invasive ...
Metabolism Holds the Key to the Senescence Secretome
A Cell Research perspective argues that cellular metabolism acts as the licensing mechanism that determines the composition and intensity of ...
Loss of Checkpoint Kinase 2 Reshapes How Cells Repair Broken DNA
A new Cell Death & Discovery study shows that checkpoint kinase 2 deficiency alters how cells engage homologous recombination and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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