Lab-grown glioblastoma stem cells reveal how tumors evolve treatment resistance
A new ex vivo platform derives temozolomide- and radiation-selected glioblastoma stem-like cells from the same primary tumor, exposing mismatch-repair loss, ...
Tag: DNA damage response
WEE1 kinase guards quiescent cells’ path back into the cell cycle
A Nature study shows that the WEE1 kinase promotes cell cycle re-entry from quiescence by phosphorylating CDH1 to inhibit the ...
Light-Driven Calcium Pulses Reveal How Cells Decode Signaling Timing
Researchers used optogenetic melanopsin stimulation in HeLa cells to show that the timing pattern of light-evoked calcium signaling selectively shapes ...
Review Proposes Chronic DNA Damage Signaling as an Aging Framework
A peer-reviewed review proposes that chronic DNA damage response signaling may connect senescence, inflammation and other aging processes, while emphasizing ...
UV radiation boosts ribosome production in Fusarium mangiferae filaments
In the plant pathogen Fusarium mangiferae, ultraviolet C radiation significantly increases ribosome levels and translation capacity in filaments, and blocking ...
Editorial: Mechanisms of drug resistance in cancer: overcoming barriers with novel pharmacological strategies
An editorial summarizing eight contributions describes cancer drug resistance as an adaptive process involving genetic, epigenetic, metabolic, signalling and microenvironmental ...
Network and cell study links carboplatin to four melanoma targets
Network analysis and B16F0 cell experiments linked carboplatin with CDKN1A, BRCA1, PTEN and AKT1 in melanoma, without establishing clinical benefit.
Whole-genome sequencing of paired prostate cancer cell cultures from 10 African American men reveals recurrent DNA-repair alterations
A prospective laboratory study that sequenced matched tumor and non-malignant primary cultures from 10 African American men with prostate cancer ...
Single ubiquitin tags on non-histone proteins shape health and disease
A comprehensive review in Cellular and Molecular Life Sciences maps how single ubiquitin marks on non-histone proteins regulate DNA repair, ...
How a Single Transcription Factor Decides Whether Sunburned Skin Cells Live or Die
New research shows that the transcription factor C/EBPβ normally restrains an inflammatory interferon and TNF-α program that, when unleashed in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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