Tag: DNA damage response

Dutch researchers have shown that combining the bladder chemotherapy drug mitomycin C with ATR kinase inhibitors eradicates patient-derived non-muscle invasive ...

A Cell Research perspective argues that cellular metabolism acts as the licensing mechanism that determines the composition and intensity of ...

A new Cell Death & Discovery study shows that checkpoint kinase 2 deficiency alters how cells engage homologous recombination and ...

A new statistical framework called BurstLink jointly infers gene regulatory interactions and transcriptional bursting kinetics across entire gene networks from ...

A new review explains how radiation-induced CCL2/CCR2 signaling recruits immunosuppressive myeloid cells and remodels the tumor microenvironment, and why combining ...

Every time a human cell divides, it must copy roughly six billion letters of DNA—a feat accomplished by molecular machines ...

DNA double-strand breaks are among the most dangerous forms of genetic damage a cell can experience. When both strands of ...

The DNA damage response (DDR) and the immune system may look like separate defense networks, but new research underscores how ...

In triple-negative breast cancer (TNBC) that carries TP53 mutations, loss of one copy of the DNA ligase I gene (LIG1) ...

In a new study published in Cell Death Discovery, researchers report that piceatannol—a natural polyphenol—may act as a “senotherapeutic,” helping ...