DNA Damage Response Pathways Inform New Cancer Immunotherapy Strategies
The DNA damage response (DDR) and the immune system may look like separate defense networks, but new research underscores how ...
Tag: DNA damage response
LIG1 Loss Reveals Targetable Weakness Against Chemotherapy-Resistant Triple-Negative Breast Cancer
In triple-negative breast cancer (TNBC) that carries TP53 mutations, loss of one copy of the DNA ligase I gene (LIG1) ...
Piceatannol Targets Radiation-Induced Senescence Markers in a Mouse Model
In a new study published in Cell Death Discovery, researchers report that piceatannol—a natural polyphenol—may act as a “senotherapeutic,” helping ...
DNA Breaks Boost RORγt, Drive Th17 Autoimmunity
In a groundbreaking study poised to reshape our understanding of autoimmune diseases, researchers have unveiled a previously unrecognized mechanism by ...
ARHGAP11A: Pan-Cancer DNA Damage Biomarker Revealed
The quest for precise prognostic biomarkers in cancer has led researchers to explore the multifaceted roles of the Rho GTPase-activating ...
CNIO Researchers Develop the “Human Repairome”: A Comprehensive Catalogue of DNA “Scars” Paving the Way for Personalized Cancer Therapies
In a monumental leap forward for genetics and cancer research, scientists at the Spanish National Cancer Research Centre (CNIO) have ...
p53 Disrupts Mitochondria Independently of Puma, Bax
In the ever-evolving landscape of cellular biology and cancer research, few proteins have garnered as much attention and intrigue as ...
UMass Chan Scientists Challenge Traditional Views on the Mechanism of Action of Anticancer Drugs
Recent groundbreaking research conducted by scientists at UMass Chan Medical School has yielded promising insights into the mechanisms underlying the ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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