Platinum Chemotherapy, Not PARP Inhibitors, Emerges as the Main Driver of Blood Clone Expansion
New research shows carboplatin drives the expansion of TP53-mutant blood clones far more strongly than PARP inhibitors, while inherited homologous ...
Tag: DNA damage response
Insulin-Sensing FOXO Protein Guards the Genome After DNA Damage
New research in C. elegans shows that the FOXO transcription factor DAF-16 directly activates DNA repair genes to preserve genome ...
Cancer’s Guardian Protein Still Pulses After Tiny Radiation Doses, Study Finds
New research shows that the p53 tumour suppressor system in breast cancer cells retains its dynamic, oscillation-like response even at ...
DNA Repair Protein RAD54L Protects Developing Egg and Sperm Precursors from Toxic Enzyme Traps
New research in mice reveals that the DNA repair factor RAD54L protects primordial germ cells by stabilizing the E3 ligase ...
Tiny Genetic Regulators Go Awry in Rare DNA Repair Disorder, Study Finds
A new study reports that ATM-deficient ataxia-telangiectasia fibroblasts show reproducible depletion of the DNA damage response microRNAs miR-34a-5p and miR-26a-5p, ...
Systematic Review Uncovers How ATM Gene Defects Shape Blood Cancers
A new systematic review finds that mutations, methylation, and expression loss of the ATM DNA repair gene are recurrent and ...
Young Dogs With Splenic Cancer Live Far Longer on Chemotherapy, Landmark Trial Reveals
A phase I trial of propranolol plus doxorubicin found no survival benefit from the beta-blocker, but revealed that young adult ...
Tiny RNA Hubs May Steer Inflammation in Aging Cells
A new review argues that stress granules and their RNA-binding proteins act as context-dependent modulators of cellular senescence and inflammation ...
Epigenetic enzyme SMYD3 emerges as Achilles heel of gastric cancer DNA repair
New research reveals that the chromatin-modifying enzyme SMYD3 orchestrates DNA double-strand break repair in gastric cancer, and that blocking it ...
Pancreatic Cancers With ATM Defects May Respond to Irinotecan, Study Finds
A new study combining real-world clinical data with CRISPR-edited cell models shows that pancreatic cancers with ATM or CHEK2 mutations ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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