How a Single Transcription Factor Decides Whether Sunburned Skin Cells Live or Die
New research shows that the transcription factor C/EBPβ normally restrains an inflammatory interferon and TNF-α program that, when unleashed in ...
Tag: DNA damage response
DNA Damage Response Drives PD-L1 Shield That Lets Aging Cells Evade Immune Clearance
A new review proposes that the DNA damage response drives PD-L1 upregulation in senescent cells, enabling immune evasion and creating ...
RDM1 Emerges as a Master Switch Linking DNA Repair and Antioxidant Defense in Head and Neck Cancer
New research reveals that RDM1, a cytoplasmic protein with a RAD52 motif, acts as an oncogenic driver in head and ...
Chlorogenic Acid Shields Aging Gut Stem Cells Through the Fly Version of NRF2
A new GeroScience study shows that the dietary polyphenol chlorogenic acid protects aging intestinal stem cells from oxidative stress in ...
New Cancer Framework Ties Epigenetics, DNA Repair and Immunity Into One Immunogenicity Score
A new multi-omics framework proposes that tumor immunogenicity emerges only when epigenetic permissiveness, DNA damage response configuration and immune activation ...
Cytomegalovirus Hijacks Host Chromatin Remodeler MORC2 to Fuel Viral Genome Repair
A new PLOS Pathogens study shows that human cytomegalovirus induces and recruits the host chromatin remodeler MORC2 to viral replication ...
Scientists Map a Battle Plan Against One of Medicine’s Rarest and Deadliest Childhood Cancers
An international expert workshop has prioritised targets and trial designs to break the three-decade therapeutic stalemate in desmoplastic small round ...
USP7: The Double-Edged Deubiquitinase That Tumors Cannot Live Without
A new review in Cancer Cell International maps how the deubiquitinase USP7 acts as both tumor promoter and suppressor depending ...
Fruit Fly Protein Xrp1 Guards the Genome Through Two Separate Tumor-Suppressing Pathways
A new PLOS Genetics study shows that the Drosophila protein Xrp1 protects genome integrity through both a p53-dependent DNA damage ...
Tousled-Like Kinases TLK1 and TLK2 Emerge as Pan-Cancer Drivers of Genomic Instability and Immune Evasion
A pan-cancer analysis of 33 tumor types reveals that the DNA-repair kinases TLK1 and TLK2 drive genomic instability and shape ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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