Why One Antibody Rules Them All: Epistasis Blocks Broad Flu Protection
Deep mutational scanning of the CR9114 antibody reveals that epistasis and pleiotropy make cross-reactive breadth against both influenza A and ...
Tag: deep mutational scanning
Structural Analysis Reveals How H5N1 Bird Flu Hemagglutinin Could Stabilize for Human Adaptation
A computational structural analysis of H5N1 clade 2.3.4.4b hemagglutinin reveals multiple independent molecular mechanisms by which mutations could raise the ...
AI Model Fills the Gaps in Protein Mutation Maps
A new gradient boosting framework called VEFill accurately imputes missing deep mutational scanning scores across protein domains, outperforming existing methods ...
Scientists engineer a miniature CRISPR protein to silence genes and curb hepatitis B
Researchers discovered a naturally nuclease-dead miniature CRISPR protein, engineered it into the hypercompact xCas12m, and showed that a single-AAV xCas12m–CRISPRoff ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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