313TE targets IL-13Rα2-positive tumors in preclinical testing
A preclinical study reports that the IL-13E13Y-based T-cell engager 313TE linked IL-13Rα2-positive tumor cells to T cells, promoting receptor-dependent killing ...
Tag: cytotoxicity
CCL21-ICAM1 synthetic niche accelerates lytic hit delivery by OT-I T cells against B16 melanoma in vitro
In a two-dimensional mouse-cell study, CCL21-ICAM1 conditioning was associated with an approximately fourfold increase in the model-estimated lytic hit-delivery rate ...
Cell assays and molecular modeling assess 1,2,3-thiadiazole derivatives against cancer cell lines
A cell-based and computational study found compound 5g had the highest measured cytotoxic activity in most tested cancer cell lines ...
Piper betle leaf oil shows cell cytotoxicity and antioxidant activity in vitro
An in vitro study found antioxidant activity in four assays and concentration-dependent cytotoxicity against KB oral carcinoma cells, with an ...
Garlic compound reduces uterine fibroid cell viability in culture
S-allylcysteine reduced uterine leiomyoma cell viability in primary culture while altering expression of PI3K/AKT-related genes, without establishing clinical efficacy.
New Dung Fungus From Kenya Yields Novel Alkaloid With Antibacterial and Anticancer Potential
A newly described coprophilous fungus from Kenyan cow dung, Schizothecium keniense, produces the novel alkaloid pyrrospirone Z and other decahydrofluorene ...
Brazilian Tree Branches Yield New Triterpene With Selective Activity Against Leukemia Cells
Chemists isolated a never-before-seen lupane triterpene and a leukemia-selective compound from the branches of a traditional Brazilian medicinal shrub.
Fungus hiding on a rare Spanish plant yields potent new anticancer molecule
Deep in the arid zones of Andalusia, a microscopic fungus living quietly on the surface of an endemic plant has ...
Lipid Nanocapsules Boost Intestinal Permeability of Antiparasitic Triterpenes for Oral Delivery
The biopharmaceutical classification framework provides useful context for interpreting the permeability results reported in this study. Compounds with apparent permeability ...
Brazilian Anti-Cancer Plant Yields Three New Molecules and a Structural Surprise
A comprehensive phytochemical study of a Brazilian medicinal plant has yielded three new bioactive molecules, revised the structures of two ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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