Cryo-EM Reveals How the ATR Checkpoint Kinase Flips Its Molecular Switch
New cryo-EM structures of human ATR–ATRIP in multiple functional states reveal how ATP priming, TopBP1 binding and autophosphorylation activate the ...
Tag: cryo-electron microscopy
Small-Molecule Inhibitors Block NorA Efflux by Conformational Trapping
Researchers show that small-molecule inhibitors shut down the Staphylococcus aureus NorA efflux pump by trapping the transporter in nonproductive conformational ...
Polyubiquitin Repositioning Reshapes Pathological Tau Fibril Structures in Dementia
Cryo-electron microscopy reveals that repositioned polyubiquitin chains outside the ordered core can remodel tau fibril ultrastructure and shift the protofilament ...
Cryo-EM Reveals the Dynamic Machinery That Switches Genes On
A new Nature Reviews Molecular Cell Biology review synthesizes cryo-EM structures showing how TFIID, Mediator, and the +1 nucleosome orchestrate ...
Cryo-EM Reveals How Cas12a Uses a DNA Guide to Hunt RNA Targets
A new cryo-EM structure of Acidaminococcus sp. Cas12a reveals how the enzyme uses a DNA guide and structural mimicry to ...
Cryo-EM Captures Hidden Pre-Active State That Switches On the Brain’s Fastest Receptors
Time-resolved cryo-electron microscopy with full and partial agonists has revealed the elusive pre-active state and complete gating pathway of AMPA ...
Unique amyloid-β filament structure found in APP Flemish mutation carriers
Cryo-electron microscopy has revealed an entirely new amyloid-β filament fold in the brains of individuals carrying one of the rarest ...
Protein nanocrates overcome air–water interface artifacts in cryo-EM
Cryo-electron microscopy has transformed structural biology by allowing scientists to visualize proteins and other biological machines at near-atomic resolution. Yet ...
Structure Reveals How Trypanosome Mitochondria Coordinate RNA Editing Cascade
Trypanosome mitochondria rely on an RNA-editing process that rewrites transcripts through precisely timed uridine deletions and insertions, guided by complementary ...
Unique β-Barrel Machinery Structure Found in Bacteroidota
In a groundbreaking study published in Nature Microbiology, researchers have unveiled the intricate structure of a novel β-barrel assembly machinery ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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