LCN2 loss reduces invasion and alters stress pathways in TNBC cells
A CRISPR knockout study in MDA-MB-231 triple-negative breast cancer cells links LCN2 loss to reduced migration, invasion and substrate-dependent adhesion, ...
Tag: CRISPR-Cas9 gene editing
CRISPR Editing Route, Not Just Target Genes, Reshapes CHO Cell Lines
A systematic comparison shows that sequential and multiplex CRISPR/Cas9 workflows produce CHO cell lines with the same nine hydrolase knockouts ...
Gene-edited yeast turns fermentation vats into carotenoid factories
A new review details how metabolomics-guided CRISPR engineering of yeasts such as Saccharomyces cerevisiae and Yarrowia lipolytica is driving cost-effective, ...
Eggplant genetics and biotechnology advance crops for food security
Eggplant, one of the world's most beloved vegetables and a staple of cuisines from South Asia to the Mediterranean, is ...
SACF and GILA multi-site study evaluates CRISPR/Cas9-edited cell transformation in vitro
A new multi-site study published in Gene Therapy reports that two streamlined assays—SACF and GILA—can improve how scientists evaluate whether ...
CRISPR Gene Editing Reveals Role of Collagen Dysfunction in Cerebral Microbleeds
In a remarkable breakthrough poised to reshape our understanding of cerebral microbleeds and their contribution to neurodegenerative conditions, researchers at ...
CRISPR Fixes Wilson Disease Mutation in Stem Cells
In a groundbreaking advancement poised to transform genetic medicine, scientists have successfully harnessed CRISPR/Cas9 gene-editing technology to correct a common ...
Novel Gene Editing Technique Targets Tumors Overloaded with Oncogenes
A groundbreaking research initiative spearheaded by a consortium of scientists at the Spanish National Cancer Research Centre (CNIO) and the ...
New Arabidopsis BIK1 Alleles Confirm Immunity Role
In a groundbreaking study poised to redefine our understanding of plant immunity, researchers have unveiled novel insights into the pivotal ...
Enhanced HDR: Screening Cas9 Variants with Diphtheria Toxin
In a landmark study published in the Journal of Biomedical Science, researchers led by D. Matsumoto, K. Kubota, and Y. ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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