The Phosphatase Switch: How PP2Acα Emerges as a Drug Target for Inflammatory Bowel Disease
A new review argues that the phosphorylation-dephosphorylation balance controlled largely by the phosphatase PP2Acα acts as a master switch in ...
Tag: colitis
Dual-Target Antibody Strikes Two Inflammatory Pathways to Ease Colitis in Mice
Scientists have engineered a bispecific antibody that simultaneously blocks TL1A and IL-12/23p40, suppressing pathogenic Th1/Th17 immune responses and significantly ameliorating ...
Hidden Immune Brake Found to Keep Gut Inflammation in Check
Researchers report that the transcription factor Zbtb44, through SUMOylation-dependent interaction with T-bet, represses interferon-gamma production by T cells and thereby ...
Grapevine Leaf Extract Shows Potent Anti-Inflammatory Effects in Mouse Colitis Study
A hydroethanolic extract of Lebanese grapevine leaves significantly reduced inflammation and restored cytokine levels in a mouse model of TNBS-induced ...
Four Plant Flavonoids Show Distinct Powers Against Gut-Driven Brain Fog in Mouse Colitis
A new mouse study shows that four structurally similar dietary flavonoids protect the brain from colitis-related cognitive deficits through distinct ...
Gut Protein Claudin-2 Revealed as a Hidden Defender Against Dangerous E. coli Infections
New research in Nature Communications shows that the tight-junction protein claudin-2 protects mice from Citrobacter rodentium infection and colitis by ...
ResolVI cleans up noisy spatial transcriptomics data after segmentation goes wrong
A new probabilistic deep learning model called ResolVI corrects misassigned RNA molecules and batch effects in spatial transcriptomics data, sharpening ...
Beef Powder Shows Unexpected Anti-Inflammatory Power Against Colitis in Mice
A new mouse study found that dietary supplementation with lean Hanwoo beef powder modestly protected against chemically induced colitis by ...
Common ‘Forever Chemical’ PFNA Found to Ignite Gut Inflammation at Tiny Doses
New research shows that low-dose exposure to the forever chemical PFNA worsens intestinal inflammation by activating a caspase-11-dependent NLRP3 inflammasome ...
Nerve Injury Protein NINJ2 Emerges as a Brake on Inflammatory Bowel Disease
Researchers found that the nerve repair protein NINJ2 protects mice from inflammatory bowel disease by suppressing ZBP1-driven PANoptosis in macrophages.
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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