Chromatin maps reveal two hidden states driving colorectal cancer
A new review synthesizes single-cell chromatin accessibility studies showing that colorectal cancer is organized into two epigenomic states whose regulatory ...
Tag: Chromatin Accessibility
Scientists map the cellular blueprint that sculpts every human face
A new single-cell and spatial atlas of the developing human face identifies 56 cell states, hundreds of spatial patterning genes ...
Single-Cell Map of Gut Chromatin Reveals Which Cells Drive Crohn’s Disease Risk
A single-cell chromatin accessibility atlas of the human intestine maps regulatory programs across 29 cell types and shows that Crohn's ...
Chromatin Remodeler INO80 Emerges as Master Gatekeeper of Lymphatic Vessel Development
A new study identifies the chromatin remodeler INO80 as a critical regulator of ETS transcription factor programs required for embryonic ...
Two Genetic Programs Take Over as Autumn Chills Deepen, Plant Study Reveals
A gradual autumn-to-winter cooling experiment in Arabidopsis reveals two distinct cold-induced genetic programs, a central role for the circadian clock ...
Massive Immune Cell Atlas Traces How Genetic Variants Drive Disease From Chromatin to Gene Expression
Researchers have built a population-scale single-cell atlas of ten million immune cells that traces how disease variants act through chromatin ...
Light-Patterned DNA Tags Give Single-Cell Sequencing a Sense of Place
A new light-based barcoding technique called scSTAMP-seq stamps spatial coordinates onto individual cells using photocleavable DNA tags, enabling joint transcriptomic ...
Open Chromatin Is Not So Open: Active Genes Ride on Condensed Domains
New simulations reveal that euchromatin is mostly condensed into dense domains, with short active regulatory regions protruding on their surfaces ...
Tiny DNA Insert in a Super-Enhancer Fine-Tunes Two Cancer Genes in Breast Tumors
A common germline insertion within a bifunctional super-enhancer dampens the expression of the cancer-promoting genes LINC00636 and CD47 in breast ...
New Method Maps Both Chromatin Access and 3D Folding in Intact Tissues
A new method called Spatial-ATAC-Hi-C simultaneously maps chromatin accessibility and three-dimensional genome organization in intact tissue sections, as demonstrated on ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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