Researchers have identified that HDAC3 deacetylase activity is required to coordinate histone acetylation reprogramming and chromatin accessibility to drive major ...
A time-course investigation shows how progressive chromatin remodeling and key regulatory factors direct human embryonic stem cells into kidney organoids.
A new study reveals that chromatin accessibility changes precede gene expression during the osteogenic differentiation of porcine synovium-derived mesenchymal stem ...
An integrative multi-omics study mapped the enhancer-state landscape across breast cancer subtypes, uncovering regulatory networks and prognostic gene associations.
A new study in The EMBO Journal reveals that the cancer-linked gene E2F1 can trigger cell division via a shortcut ...
A large-scale multiomic study reveals that tandem repeat variation drives cell type-specific gene expression across human immune cells.
A new study shows that SMARCAL1 forms nuclear condensates that reprogram chromatin and methionine metabolism, weakening radiotherapy and immunotherapy responses.
A review in the Journal of Advanced Research synthesizes how single-cell chromatin accessibility studies are reshaping understanding of bone development, ...
A new review in Clinical Epigenetics distinguishes epigenetic changes proven to persist after glycemic normalization in diabetic cardiomyopathy from those ...
A population-scale single-nucleus study of 287 human skeletal muscle biopsies maps cell-type-specific eQTLs and caQTLs that colocalize with thousands of ...
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