CRISPR Editing Route, Not Just Target Genes, Reshapes CHO Cell Lines
A systematic comparison shows that sequential and multiplex CRISPR/Cas9 workflows produce CHO cell lines with the same nine hydrolase knockouts ...
Tag: CHO cells
Antibody Sugar Engineering Meets Real-Time Monitoring to Reshape Biomanufacturing
A new perspective argues that the Fc glycan of monoclonal antibodies should be treated as an intrinsic design variable, integrating ...
Shotgun genetic engineering screens millions of metabolic pathways in mammalian cells
Researchers have developed shotgun genetic engineering, a method that screens millions of randomly assembled metabolic pathways in mammalian cells and ...
Silent DNA Tweaks Boost Production of Blockbuster Arthritis Drug in Lab Cells
Korean researchers used a CHO cell-based screening platform to identify synonymous codon variants that raise etanercept productivity up to 2.75-fold ...
Shotgun genetic engineering lets mammalian cells test millions of designs at once
Researchers have developed shotgun genetic engineering, a multiplexed strategy that screens millions of combinatorial genetic designs in mammalian cells within ...
Miniature Perfusion Screens and a Manufacturability Index Reshape How Biotech Picks Its Best Cell Clones
Researchers have miniaturised a semi-perfusion clone screening method to a 96-well deepwell plate format and shown that a multi-parameter manufacturability ...
Engineered Protein Breakdown Supercharges Drug-Free Selection of High-Producing CHO Cells
Researchers at Inha University engineered destabilized glutamine synthetase variants that dramatically increase selection stringency in CHO cells, enabling drug-free isolation ...
Cyclical Cake Filtration Slashes Filter Area in CHO Cell Harvesting
A new study shows that cyclical cake filtration with diatomaceous earth and ion-exchange resins can clarify CHO cell harvests at ...
Hidden Chemical Variation in Cotton Hydrolysates Shapes Antibody Yields in Cell Culture
Chemometric analysis of cottonseed hydrolysates reveals that batch-to-batch chemical variability significantly influences CHO cell culture longevity, antibody productivity, and antibody ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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