Scientists Find a Shared Weakness That Could Crack Triple-Negative Breast Cancer’s Drug Resistance
New research shows that triple-negative breast cancer cells rely on shared DNA damage tolerance enzymes such as POLζ and CHK1 ...
Tag: Chk1
How replication stress shapes cancer evolution and opens new doors for therapy
A comprehensive new review explains how replication stress drives cancer genome evolution and why the pathways cells use to survive ...
Cryo-EM Reveals How the ATR Checkpoint Kinase Flips Its Molecular Switch
New cryo-EM structures of human ATR–ATRIP in multiple functional states reveal how ATP priming, TopBP1 binding and autophosphorylation activate the ...
ATR Inhibitor Ceralasertib Restores Trifluridine’s Power Against Drug-Resistant Colorectal Cancer
New preclinical research shows that the ATR inhibitor ceralasertib (AZD6738) synergistically restores and amplifies the antitumor activity of trifluridine in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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