Aging Cells Lose Their Recycling Machinery, Letting Senescent Cells Pile Up
New research in Nature Aging shows that the age-related decline of chaperone-mediated autophagy distorts the senescent cell secretome and disables ...
Tag: chaperone-mediated autophagy
Cellular Recycling Pathway Emerges as Central Driver of Ageing and Disease
A new review argues that chaperone-mediated autophagy, the cell's most selective protein degradation pathway, acts as a master regulator of ...
Failing Cellular Recycling Lets Zombie Cells Pile Up as We Age, Study Finds
A new Nature Aging study from Albert Einstein College of Medicine shows that age-related decline in chaperone-mediated autophagy allows senescent ...
Oncogenic viruses hijack a lysosomal receptor to fuel cancer growth
A new Nature Microbiology study shows that oncogenic viruses hijack chaperone-mediated autophagy by inducing TRIM32-mediated SUMOylation of LAMP2A, promoting viral ...
Scientists Gather in Shanghai to Push Aging Biomarkers Toward Human Intervention Testing
A Nature Aging meeting report describes how the 6th TimePie Longevity Forum in Shanghai brought together international researchers to advance ...
Cellular Recycling in the Brain’s Appetite Center May Shape Obesity Risk
A new review argues that autophagy in hypothalamic POMC and AgRP neurons exerts opposing effects on appetite and energy balance, ...
Hidden Protein Modification Lets Pancreatic Cancer Evade Ferroptosis and Resist Chemotherapy
A new Nature Cancer study reveals how hypoxia-induced lactylation of MMSDH triggers ACSL4 degradation through propionylation, helping pancreatic cancer evade ...
Chaperone-Mediated Autophagy Fuels Muscle Stem Cells, Wanes with Age
In the intricate world of cellular biology, the preservation of proteostasis emerges as a crucial determinant of stem cell functionality ...
Chaperone-Mediated Autophagy Regulates Energy Under Heat
In a groundbreaking study recently published in Nature Communications, a team of researchers led by Zhuang, Zhang, and colleagues unveils ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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