Blocking a Glutamine Enzyme Restores Aging Muscle Power in Mice
University at Buffalo researchers found that inhibiting the glutamine-metabolizing enzyme GLS1 with the drug CB-839 reduced urea buildup, restored mitochondrial ...
Tag: Cellular senescence
Metabolic Protein ANGPTL8 Found to Accelerate Aging of Blood Stem Cells
New research shows that the metabolic protein ANGPTL8 drives the aging of hematopoietic stem and progenitor cells by binding the ...
Aging Gut Microbes Weaken Flu Defenses, but Acetate Restores Protection in Old Lung Cells
New research in Aging Cell shows that age-related gut microbiota dysbiosis reduces acetate production and weakens antiviral defense in the ...
Senolytic Drugs and Aerobic Exercise Each Rejuvenate the Aging Mouse Heart
A nine-month study in mice shows that chronic senolytic treatment and aerobic exercise each reduce senescent cell markers in the ...
Exploding immune cells may explain why prostate drug therapy fails in some men
A new study shows that 5-alpha-reductase inhibitor therapy can trigger macrophage pyroptosis, HMGB1–AGER-driven epithelial senescence and club-cell reprogramming in the ...
Anti-ageing drug combo clears senescent cells and reverses liver scarring in first randomized trial
A phase-2 randomized trial shows intermittent dasatinib plus quercetin significantly improved liver fibrosis and resolved MASH in nearly half of ...
Senolytic Drugs Show Promise Against Bone Loss Caused by Chemotherapy
A new mouse study shows that senolytic drugs targeting senescent cells can partially mitigate the bone loss and marrow fat ...
New Database Maps 3,111 Genes Across the 11 Hallmarks of Aging
Researchers in India have launched AgingHallmarksDB, an interactive platform integrating 3,111 aging-associated genes across the eleven hallmarks of aging with ...
Engineered Flavonoid Cousins of Fisetin Clear Senescent Cells and Boost Healthspan in Mice
Researchers engineered two fisetin-derived flavonoid analogs that kill senescent cells up to 27 times more potently than fisetin and reduce ...
Mini-GRID Radiotherapy Curbs Cellular Senescence While Keeping Its Anti-Tumor Punch in Glioma Cells
A preclinical study finds that spatially fractionated mini-GRID radiotherapy preserves the growth-inhibitory effect of radiation in glioma cells while markedly ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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