Gut Bile Acid Rejuvenates Aging Bone Stem Cells to Fight Postmenopausal Osteoporosis
A gut bacteria-derived bile acid called hyodeoxycholic acid restores aging bone marrow stem cells and reverses bone loss in a ...
Tag: Cellular senescence
Tiny Cellular Shuttles Drive Aging in Chronic Lung Disease, Review Finds
A new review in the Chinese Medical Journal details how extracellular vesicles spread cellular senescence across chronic lung diseases and ...
Aging Fibroblasts Fuel Ovarian Cancer Growth Through a Single Secreted Protein
New research shows that senescent cancer-associated fibroblasts in high-grade serous ovarian cancer secrete Tenascin-C, which activates SDC4-ERK signaling in tumor ...
How a Single Glycolytic Enzyme Decides Whether Cancer Cells Grow or Senesce
A new study in Advanced Science shows that losing the glycolytic enzyme TPI1 causes DHAP to accumulate and activates a ...
How Failing Mitochondria Turn Cells Into Engines of Ageing Inflammation
A new GeroScience review details how failing mitochondria act as both initiators and amplifiers of cellular senescence and the chronic ...
Hidden p53 Variant Δ246p53 Emerges as a DNA Damage Sentinel Driving Cellular Senescence
Researchers have discovered Δ246p53, a conserved 18-kilodalton p53 isoform translated from codon 246 that responds to DNA damage and enhances ...
Telomere-Linked Senescence Genes Predict Survival in Cervical Cancer, Study Finds
A new bioinformatic study in Reproductive Sciences shows that a risk model built from telomere-related senescence genes can independently predict ...
Magnetic pulses rewire a hidden nerve circuit in bone to reverse stress-driven bone loss
A new Nature Communications study reveals that pulsed electromagnetic fields protect stressed skeletons by activating a brain-independent sensory nerve circuit ...
Aging Cells Lose Their Recycling Machinery, Letting Senescent Cells Pile Up
New research in Nature Aging shows that the age-related decline of chaperone-mediated autophagy distorts the senescent cell secretome and disables ...
Dementia May Not Be a Brain Disease at All, NIH Scientists Argue
NIH researchers argue that dementia may be the late-life manifestation of a systemic failure of energy regulation rather than a ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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