Blood Clues Before Surgery Predict Who Will Reject a New Liver
Single-cell sequencing of blood samples taken before and after liver transplantation reveals immune signatures that predict which patients will suffer ...
Tag: CD8+ T cells
RNA Tagging Enzyme METTL16 Fuels Colorectal Cancer by Hijacking Amino Acid Metabolism and Silencing Immune Cells
New research shows that the RNA methyltransferase METTL16 drives colorectal cancer growth and immune evasion by stabilizing BCAT1 mRNA and ...
Macrophage Exosomes Disarm Immune Cells and Fuel Ovarian Cancer Spread
A new study shows that exosomes released by tumor-associated macrophages carry PD-L1 that reprograms the metabolism of CD8-positive T cells, ...
Bacteria Inside Liver Tumors May Predict Who Responds to Cancer Conversion Therapy
Researchers found that liver cancer patients who responded poorly to conversion therapy harbored distinct bacterial communities inside their tumors, including ...
Common Bile Acid Drug Unlocks a Hidden Human Brake on Radiation-Driven Cancer Immunity
Researchers have identified a human-specific FXR-TRIM22-STAT1 checkpoint that suppresses radiation-induced antitumor immunity, and shown that the clinically approved bile acid ...
How Malaria Parasites Punch Through Cells to Spark Protective Immunity
New research shows that the damage malaria sporozoites inflict while punching through host cells, sensed via a wounding response requiring ...
Collagen Receptor CD49b Emerges as Key Switch That Lets Breast Tumors Hide From Immunotherapy
Blocking the collagen receptor integrin alpha-2 (CD49b) on breast cancer cells remodels the tumor immune microenvironment and synergizes with anti-PD-L1 ...
NAD+ Collapse Drives Senescent CD8+ T Cells That Worsen Ulcerative Colitis
A new study in Aging Cell shows that NAD+ metabolic collapse drives senescent CD8+ T cells to fuel ulcerative colitis ...
Gut Microbe’s Stress-Linked Metabolite Drives Breast Cancer Spread, and an Ancient Drug Blocks It
New research traces how chronic stress fuels breast cancer metastasis through a gut bacterium's tryptophan metabolite and shows that the ...
Immune Cells Cluster, Not Crowd, in Melanoma That Spreads to the Brain
A Dutch study finds that melanoma brain metastases harbor far fewer but more tightly clustered immune cells than other metastases, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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