Hidden armies inside glioblastoma: exhausted T cells hint at new immunotherapy routes
Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be ...
Tag: CD8+ T cells
Metabolic Weak Point Found in Exhausted Immune Cells in Head and Neck Cancer
Johns Hopkins researchers measured the metabolism of immune cells inside human head and neck tumors and found that exhausted T ...
Liver Cancer Gene GNG4 Found to Build Walls That Keep Immune Cells Out of Tumors
New research links the gene GNG4 in malignant liver cells to tumor immune exclusion and reduced CD8-positive T cell infiltration ...
Chemotherapy Found to Supercharge Cancer Vaccines When Timed Just Right
Researchers at Ludwig Oxford have discovered that chemotherapy regimens such as CarboTaxol can act as adjuvants that dramatically boost cancer ...
Zinc Nanovaccine Retrains Immune Cells to Attack Lung Cancer
A mannose-decorated zinc metal-organic framework nanovaccine delivering the tumor antigen CLDN6 reprograms immunosuppressive macrophages in lung tumors into antigen-presenting cells ...
IDO1 Inhibitor Plus Melanoma Vaccine Fails to Boost Tumor-Fighting T Cells in Trial
A phase II pilot trial found that the IDO1 inhibitor epacadostat safely reduced kynurenine-to-tryptophan ratios in advanced melanoma patients but ...
Kidney Cells Caught Dispatching Exosomes That Ignite Immune Attack in Nephrotic Syndrome
New research shows that injured kidney podocytes release exosomes carrying MHC-I antigen-presenting machinery that activates CD8-positive T cells directly and, ...
Chemotherapy Preconditioning Fails to Boost Inhaled IL-15 Immunotherapy in Dogs with Lung Metastases
A UC Davis clinical trial found that doxorubicin lymphodepletion before inhaled interleukin-15 therapy did not improve response rates in dogs ...
BK Virus Kidney Infection Shows Broad Immune Disruption in Transplant Patients
A combined transcriptomic and histological study of kidney biopsy tissue reveals widespread immune activation, checkpoint upregulation, and altered T-cell dynamics ...
Hidden T-Cell Clones Are Surprisingly Common in JAK2-Mutated Blood Cancers
A retrospective study of 354 patients found clonal T-large granular lymphocyte expansions in 17.2 percent of JAK2-mutated myeloproliferative neoplasm cases, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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