Iron-Powered Cell Death Emerges as Double-Edged Sword in Cancer’s Microenvironment
A new review in Medical Oncology maps how the tumor microenvironment can either amplify or suppress ferroptosis, the iron-dependent cell ...
Tag: CD8+ T cells
A Tiny Dose of Radiation Could Stop Cancer From Spreading to the Liver
A single 2 Gy prophylactic dose of liver radiation reprograms hepatic immune cells via an SAA1–TLR2–CXCL10 signaling axis to recruit ...
mRNA Vaccine Paired With Radiotherapy Shrinks HER2-Positive Lung Tumors in Mice
A HER2-targeted mRNA lipid nanoparticle vaccine combined with fractionated radiotherapy suppressed tumor growth and reprogrammed the immune microenvironment in a ...
Hidden armies inside glioblastoma: exhausted T cells hint at new immunotherapy routes
Single-cell analysis of 56 glioblastoma tumors reveals that T-cell-rich cases harbor clonally expanded, LAG3-high CD8 T cells that may be ...
Metabolic Weak Point Found in Exhausted Immune Cells in Head and Neck Cancer
Johns Hopkins researchers measured the metabolism of immune cells inside human head and neck tumors and found that exhausted T ...
Liver Cancer Gene GNG4 Found to Build Walls That Keep Immune Cells Out of Tumors
New research links the gene GNG4 in malignant liver cells to tumor immune exclusion and reduced CD8-positive T cell infiltration ...
Chemotherapy Found to Supercharge Cancer Vaccines When Timed Just Right
Researchers at Ludwig Oxford have discovered that chemotherapy regimens such as CarboTaxol can act as adjuvants that dramatically boost cancer ...
Zinc Nanovaccine Retrains Immune Cells to Attack Lung Cancer
A mannose-decorated zinc metal-organic framework nanovaccine delivering the tumor antigen CLDN6 reprograms immunosuppressive macrophages in lung tumors into antigen-presenting cells ...
IDO1 Inhibitor Plus Melanoma Vaccine Fails to Boost Tumor-Fighting T Cells in Trial
A phase II pilot trial found that the IDO1 inhibitor epacadostat safely reduced kynurenine-to-tryptophan ratios in advanced melanoma patients but ...
Kidney Cells Caught Dispatching Exosomes That Ignite Immune Attack in Nephrotic Syndrome
New research shows that injured kidney podocytes release exosomes carrying MHC-I antigen-presenting machinery that activates CD8-positive T cells directly and, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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