Synthetic Viral RNA Shrinks NF1 Brain Tumors by Reprogramming Immune Cell Signaling
Poly(I:C), a synthetic double-stranded RNA, durably suppressed NF1-associated optic pathway glioma growth in mice by engaging TLR3 and MDA5 pathways ...
Tag: CD8+ T cells
Immune Cell Genes Track Ferroptosis Signals in Kidney Cancer
A multi-cohort study finds that five genes upregulated in clear cell renal cell carcinoma mark the immune microenvironment rather than ...
High blood sugar reprograms T cells to fight tumors in mouse study
A mouse study in The Journal of Immunology reports that hyperglycemia reprograms T cells through an IGF1-IGF1R signaling pathway to ...
Taurine-loaded nanoparticles combine photothermal therapy and immune modulation against gastric cancer in mice
Hyaluronic acid-modified taurine-polydopamine nanoparticles combined photothermal therapy with taurine-driven immune modulation to suppress gastric tumors in mice.
CREBBP mutation drives lymphoma growth and T-cell exhaustion via NOTCH pathway
A new study reports that the recurrent CREBBP Y1503C mutation promotes diffuse large B-cell lymphoma growth and CD8+ T-cell dysfunction ...
Pollen Polysaccharide With Complex Pectic Architecture Boosts Dendritic Cell Maturation
A structurally complex pectic polysaccharide from Typha angustifolia pollen promoted maturation of mouse bone marrow-derived dendritic cells and enhanced antigen-specific ...
Stronger CD8 T-cell responses linked to lower inducible HIV transcription on long-term ART
In Ugandan adults after more than a decade of suppressive ART, stronger HIV-specific CD8⁺ T-cell effector responses were associated with ...
Short-Term CD8+ T Cell Depletion Alters Tau Pathology in Aged Alzheimer’s Model Mice
Brief antibody-mediated depletion of CD8+ T cells in aged APP/PS1 mice left amyloid plaques unchanged but reduced dystrophic neurites and ...
ERAP1 Haplotypes Linked to Poorer Survival in Cervical Cancer Patients
A study of TCGA and Brazilian cervical cancer cohorts found that two ERAP1 haplotypes were associated with significantly worse survival ...
Cediranib plus KRASG12C inhibitors triggers replication stress and antitumor immunity
A new study reports that combining the multi-target kinase inhibitor cediranib with KRASG12C inhibitors overcomes resistance by sustaining ERK blockade, ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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