The Fat Signal: How 2-AG Rewires Obesity, Inflammation and Metabolism
A new review argues that the endocannabinoid 2-arachidonoylglycerol acts as a central signaling hub linking appetite, fat storage, insulin resistance, ...
Tag: CB1 receptor
Brain’s own cannabis-like signal acts as a brake on PTSD-like behavior in mice
A mouse study reveals that endocannabinoid 2-AG signaling in the oval bed nucleus of the stria terminalis acts as a ...
Runner’s High Mapped in Real Time: Anandamide Soars Through Marathons and Ultramarathons
Two field studies of marathon and ultramarathon runners show that anandamide rises progressively during hours of running while 2-AG responds ...
Blocking the Brain’s Cannabis Receptor Repairs Faulty RNA Splicing in Fragile X Mice
A new study in iScience shows that blocking the cannabinoid CB1 receptor with low-dose rimonabant reverses disease-associated alternative splicing defects ...
Precision Psychiatry Takes Aim at Cannabis Use Disorder Through Brain Chemistry and Genes
A new Translational Psychiatry review argues that integrating endocannabinoid neurobiology, genetic risk loci, and early-phase drug trials could finally enable ...
Cannabis Receptors in the Womb: How the Endocannabinoid System May Drive Endometriosis Pain
A new review in Reproductive Sciences argues that the body's endocannabinoid system, acting through inflammation, pain signaling, and lesion growth ...
Zebrafish Put Two New Synthetic Cannabinoids to the Test, With Surprisingly Mild Results
A new zebrafish study finds that two emerging synthetic cannabinoid receptor agonists, ADB-INACA and CHO-4′Me-5′Br-FUBOXPYRA, show low toxicity, normal social ...
Obesity Pill Pep19 Rebalances Body Fat Without Weight Loss in Trial
A 90-day randomized trial in Brazil found that the oral peptide Pep19 significantly improved abdominal fat distribution, HbA1c, and insulin ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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