A computational finite element framework reveals how physical overloading triggers acute protease release while cytokine diffusion sustains long-term cartilage degradation ...
Researchers identified a recurrent cholesterol-homeostasis gene signature in human osteoarthritis cartilage and showed that silencing transcription factor SREBF1 alters lipid ...
Researchers published a computational study in BMC Biotechnology identifying P4C-BM as an early-stage candidate for inhibiting matrix metalloproteinase-13, an enzyme ...
In mouse and chondrocyte models, KAT7 was shown to drive osteoarthritis cartilage degeneration by epigenetically activating Nlrp3 transcription via H3K14 ...
A new review argues that the hip's cotyloid fossa fat pad is a promising but still uncharacterized source of therapeutic ...
A laboratory study in immortalized human chondrocytes reports that high concentrations of metformin trigger caspase- and ROS-dependent apoptosis in senescent ...
A new review in Amino Acids synthesizes evidence on how glucosamine sulfate and chondroitin sulfate act on cartilage, interact with ...
A biomimetic coacervate that binds cartilage, lubricates joints and delivers anti-inflammatory drugs and stem cells reduced cartilage degradation in rat ...
University of Illinois Chicago researchers have developed a 4D bio-kirigami platform in which patterned, cell-laden hydrogels autonomously bend and fold ...
Humans walk upright, carry brains three times larger than those of our closest relatives, and possess slender, distinctly shaped skeletons. ...
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