Cellular Nibbling: How Trogocytosis Shapes Immunity, Cancer, and Infection
A new review examines how trogocytosis, the process by which cells nibble membrane fragments from one another, shapes immune regulation, ...
Tag: CAR T cells
Immune Checkpoint Blockers and Engineered Cells Reshape the Fight Against Oral Cavity Cancer
A new review in Molecular Biology Reports maps how checkpoint inhibitors, engineered cell therapies, and emerging immunotherapies are transforming treatment ...
Grid-Shaped Radiation Beats Conventional Beams in Boosting CAR T Therapy for Brain Lymphoma
A rat study shows that spatially fractionated minibeam radiation, unlike conventional radiotherapy, preserves the efficacy of CD19-directed CAR T cells ...
Global AI protein design contest puts 12,000 computer-made cancer binders to the test in living T cells
A global competition benchmarked 12,000 AI-designed CD20 binders in primary human CAR-T cells, revealing common design failure modes and simple ...
AI-Designed Protein Binders Face Real-World Test in Landmark CAR T Cell Competition
A crowdsourced competition called Bits to Binders tested 12,000 AI-designed minibinders as CAR T cell recognition domains, revealing both the ...
Engineered Macrophages Emerge as a New Frontier in Cell Therapy for Solid Tumors
A new review details how chimeric antigen receptor-engineered macrophages are overcoming the barriers that stalled CAR-T therapy in solid tumors, ...
Lipid Nanoparticles Deliver CAR Instructions to T Cells Without Viruses
Researchers have engineered a custom ionizable lipid nanoparticle that delivers CAR-encoding mRNA into human T cells with over 90 percent ...
Viruses That Board CAR Cells: A Modular Push Against Solid Tumors
A new review proposes co-designing oncolytic viruses and CAR-T or CAR-NK cells as a modular, self-amplifying therapeutic system to overcome ...
Bird-Derived Jumping Gene Rewritten to Insert DNA into Human Cells with RNA Alone
Researchers mined 1,139 avian genomes for R2 retrotransposons and engineered variants that achieve up to 60 percent site-specific, all-RNA-mediated gene ...
AI Watches CAR T Cells Destroy Tumors in Real Time Inside Patient-Derived Organoids
Researchers have combined patient-derived pancreatic tumor organoids with a deep learning algorithm called OrganoIDNet to automatically track in real time ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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