Engineered IL-6-Responsive CAR Macrophages Boost CAR-T Cell Activity Against Solid Tumors
Engineered IL-6-responsive CAR macrophages enhanced CAR-T cell antitumor activity, matrix remodeling, and survival in preclinical solid tumor models.
Tag: CAR T cells
CD84 Levels Predict Venetoclax Response in Acute Myeloid Leukemia
High CD84 expression correlates with venetoclax resistance in AML, and targeting the CD84-SESN2 pathway sensitized leukemia cells to the drug ...
Dormant Until They Reach the Brain: Engineered CAR-T Cells Clear a Lethal Pediatric Tumor in Mice
UC San Francisco scientists engineered B-SYNC CAR-T cells that activate only in the brain and cleared diffuse midline glioma in ...
Computational agent pinpoints ADAM17 as drug target in biliary tract cancer
An AI-driven target discovery framework ranked ADAM17 first for biliary tract cancer, and antibody-drug conjugates and CAR-T cells built against ...
New framework proposes how to pick safer targets for senolytic immunotherapy
A proposed four-criteria framework for selecting senescence-associated antigens finds that neither uPAR nor GPNMB currently meets all requirements.
Preclinical thyroid cancer study restores CAR-T target with targeted drugs
A preclinical Mayo Clinic study found that MAPK inhibitors restored TSHR on anaplastic thyroid cancer cells and improved tumor control ...
Preclinical plug-and-play CAR T cells can be reconfigured after treatment
An animal study by City of Hope researchers shows that modular CAR T cells can accept engineered adaptors after treatment, ...
mRNA-encoded antibodies show early clinical promise in cancer therapy
A Journal of Translational Medicine review outlines how mRNA-encoded antibodies, bispecific constructs, and transient CAR expression could overcome the manufacturing ...
Gastric protein CLDN18.2 emerges as candidate biomarker in mucinous colorectal cancer
A new review finds that the gastric tight-junction protein CLDN18.2, rare in conventional colorectal cancer, is enriched in mucinous colorectal ...
ARPA-H funds cyborg cells for room-temperature therapy storage
A UC Davis-led project funded by up to $36.5 million will test whether intracellular polymer gels can stabilize therapeutic cells ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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