MUC1: The Sticky Protein That Turns Guardian of Epithelia Into Engine of Cancer
A sweeping new review maps how the epithelial guardian protein MUC1, and especially its MUC1-C signaling subunit, is hijacked by ...
Tag: CAR T cells
Lipid Nanoparticle CAR Engineering Reveals Synergy Between T Cells and Macrophages Against Leukemia
A new study shows that lipid nanoparticle-delivered CAR mRNA engineers both human T cells and macrophages against CD19-positive leukemia cells, ...
Lab-Grown Brain Tumors Put Patient Immune Systems to the Test
A new review argues that patient-derived glioblastoma organoids could finally provide a realistic platform for testing immunotherapies, including oncolytic herpes ...
Miniature Brain Tumors in a Dish Offer New Hope for Beating Immunotherapy Resistance
A new review in the Journal of Translational Medicine describes how brain tumor organoid platforms are being used to reconstruct ...
How Tumor Mitochondria Help Cancer Hide From the Immune System
A new review in the Journal of Translational Medicine details how mitochondrial metabolic reprogramming in tumor cells drives immune evasion ...
Global Platform Trial Aims to Transform Treatment of Children With Relapsed B-Cell Lymphoma
An international adaptive platform trial called Glo-BNHL will simultaneously test bispecific antibodies, antibody-drug conjugates and CAR T-cells in children and ...
Chaperone Blockade Turns a Hidden Stress Protein Into a Target for CAR Immunotherapy
New research shows that blocking the HSP90 chaperone forces stressed tumor cells to display GRP78 on their surface, making drug-resistant ...
Zirconium-89 PET Tracks Immune Cells Safely in First Human Trial
A first-in-human trial shows that white blood cells labeled with zirconium-89 can be safely tracked with PET/CT, achieving a lower-than-predicted ...
T Cell-Engaging Antibody Clears Aging Cells in Mice and Monkeys, With Liver Enzymes as a Built-In Safety Gauge
A uPAR-targeting bispecific T-cell engager safely cleared senescent cells in aged mice and rhesus macaques, with serum liver enzymes serving ...
Engineered CAR-T Cells That Make Their Own IL-2 Show Stronger Staying Power Against Pancreatic Cancer
A preclinical study shows that CAR-T cells engineered to secrete an Fc-fused IL-2(C125S) variant persist longer, retain mitochondrial fitness, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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