RNA Editing Enzyme ADAR1 Emerges as Key Switch That Turns Cold Bladder Tumors Hot
Researchers found that inhibiting the RNA editing enzyme ADAR1 reprograms the immunosuppressive tumor microenvironment of bladder cancer and sensitizes it ...
Tag: cancer immunotherapy
Scientists Reverse Radiotherapy Resistance in Lung Cancer by Rewiring the Immune Microenvironment
New research shows that lung tumors become radioresistant through ATR signaling activation and immune suppression, but innate immune agonists and ...
Personalized Neoantigen Vaccine Turns a Patient’s Immune System Into a TCR Discovery Engine
A personalized dendritic cell neoantigen vaccine given to an ovarian cancer patient enabled Swiss researchers to track expanding T-cell clonotypes ...
Gut Bacteria Sugar Turns Itself Into a Cancer Vaccine Supercharger
Scientists have transformed a sugar molecule produced by gut bacteria into a self-assembling nanovaccine that dramatically boosts antitumor immunity and ...
Dual T-Cell Activator Breathes New Life Into Checkpoint Therapy for Resistant Cancers
A selective dual T-cell activator directed at the TCR beta chain revives exhausted antitumor T cells and sensitizes checkpoint-resistant cancers ...
Tetraspanin Protein Supercharges CAR-T Cells by Amplifying IL-2 Signaling
Researchers report that the membrane protein TSPAN32 enhances CAR-T cell potency by assembling the IL-2 receptor complex and amplifying intracellular ...
Novel Plasmid Combination Injected Directly into Tumors Drives Strong Regression of Metastatic Melanoma
Researchers report that a novel combination of plasmids delivered directly into tumors induces high levels of regression in metastatic melanoma, ...
Hidden Enzyme KMT9 Helps Prostate Tumors Evade Immune Attack
New research reveals that the epigenetic enzyme KMT9 orchestrates immune evasion in prostate cancer by recruiting suppressive myeloid cells and ...
Ancient Viral Fossils in Tumors Reveal Targets That Drive Anti-Metastatic Immunity in Breast Cancer
New research shows that T cell responses against endogenous retroviral peptides, particularly murine leukemia virus fragments, are critical for checkpoint ...
Mapping STING Mutations to Unlock Immunity and New Therapies
A comprehensive atlas of STING mutations consolidates genetic, structural, and clinical data to clarify how variants drive autoinflammation, immunodeficiency, and ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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