Jaw joint disc traced to a tendon, not the condyle, in mouse embryos
Developmental tracing in mice shows the TMJ disc forms independently of the condyle with a tendon-like molecular signature, supporting its ...
Tag: bulk RNA-seq
New BLASE tool maps bulk RNA-seq samples onto single-cell trajectories
A new open-source R package called BLASE maps bulk RNA-seq samples onto single-cell pseudotime trajectories, outperforming existing deconvolution tools in ...
New computational tool unearths hidden cell-type signals in bulk and spatial transcriptomics
A benchmarked computational framework called BayesPrism-DWLS infers cell-type proportions and cell-type-specific gene expression from bulk RNA-seq and spatial transcriptomics data ...
New ESMF Method Sharpens Cell-Type Estimates from Bulk RNA Sequencing Data
A new deconvolution framework called ESMF uses single-cell reference data, negative binomial noise modeling and dual-validated marker selection to estimate ...
Monocytes, Not T Cells, Show Strongest Gene Disruption in Multiple Sclerosis
A reanalysis of bulk RNA-sequencing data from multiple sclerosis patients finds that CD14+ monocytes show the most extensive transcriptional and ...
New AI Framework Maps Drug Sensitivity Down to Individual Cells in Bulk Tumor Samples
A new two-step machine-learning framework called CLIMB and CLIFF computationally deconvolves bulk RNA-seq and drug sensitivity data into cell-type and ...
Dual-Branch AI Framework CrossBranch Sharpens Cell-Type Maps Across Omics Data
A new dual-branch deep learning framework called CrossBranch improves the estimation of cell-type composition from bulk, proteomic, and spatial omics ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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