CRISPR Editing Route, Not Just Target Genes, Reshapes CHO Cell Lines
A systematic comparison shows that sequential and multiplex CRISPR/Cas9 workflows produce CHO cell lines with the same nine hydrolase knockouts ...
Tag: biopharmaceutical manufacturing
CFD framework maps hydrodynamic design space for bioreactor process transfer
A CFD-based framework using power dissipation per unit volume, shear stress, and mixing time defines a quantitative hydrodynamic design space ...
Antibody Sugar Engineering Meets Real-Time Monitoring to Reshape Biomanufacturing
A new perspective argues that the Fc glycan of monoclonal antibodies should be treated as an intrinsic design variable, integrating ...
Engineered Protein Breakdown Supercharges Drug-Free Selection of High-Producing CHO Cells
Researchers at Inha University engineered destabilized glutamine synthetase variants that dramatically increase selection stringency in CHO cells, enabling drug-free isolation ...
Hidden Chemical Variation in Cotton Hydrolysates Shapes Antibody Yields in Cell Culture
Chemometric analysis of cottonseed hydrolysates reveals that batch-to-batch chemical variability significantly influences CHO cell culture longevity, antibody productivity, and antibody ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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