Why Antigen Expression Alone Cannot Predict Response to B7-H3-Targeted Cancer Therapy
A new review argues that B7-H3 positivity measured by immunohistochemistry is necessary but not sufficient to predict response to antibody-drug ...
Tag: biomarker
White Matter Is Not Silent: Hidden Brain Networks Shift Early in Alzheimer’s Disease
A large resting-state fMRI study of 789 ADNI participants shows that white matter functional networks are measurably and selectively disrupted ...
A Hidden RNA Splice Variant May Predict Relapse After CD19 CAR-T Therapy
Danish researchers report that low-level skipping of CD19 exon 2, detectable in pre-treatment RNA-sequencing data, correlates with relapse after anti-CD19 ...
Blood Urea Nitrogen Emerges as a Powerful Predictor of Survival in Critically Ill Multiple Myeloma Patients
A retrospective cohort study using the MIMIC-IV database found that elevated blood urea nitrogen within 24 hours of ICU admission ...
New Python Package Puts Biomarker Discoveries to the Test Before They Reach the Clinic
A new open-source Python package called ROOFS benchmarks multiple feature selection methods on a researcher's own data, evaluating predictive performance ...
Blood Gene Signature Tied to STAT3 and ARG1 Reveals Immune Shutdown in Sepsis
Researchers have identified a STAT3/ARG1-associated myeloid immunosuppressive gene signature in sepsis blood that shows strong diagnostic performance across two independent ...
Rat Incisors Reveal How Diabetes Drives Inflammatory Cell Death in Teeth
New research links slowed incisor growth in diabetic rats to oxidative stress and RIPK3–MLKL necroptosis signaling within the dental pulp.
Sequencing Read Counts Could Flag the Most Infectious Tuberculosis Patients
Pulmonary tuberculosis remains one of the world's most stubborn infectious diseases, and a central challenge for clinicians is telling apart ...
Low Butyrylcholinesterase Activity in Dogs Signals Inflammation but Trails CRP as a Biomarker
A large Bern study of 950 dogs shows low plasma butyrylcholinesterase activity is associated with SIRS, sepsis, and poor survival, ...
Routine Blood Test Measure Flags Higher Death Risk in Low-Income Adults
A large NHANES-based cohort study finds that elevated red blood cell distribution width is associated with increased all-cause mortality in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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