REV-ERBβ emerges as a non-redundant brake on TH17-driven inflammation
New research reveals that the circadian nuclear receptor REV-ERBβ acts as a distinct, non-redundant negative regulator of pro-inflammatory TH17 cell ...
Tag: autoimmunity
Rare Immune Genes Point to Autoimmunity in Bladder Pain Syndrome
High-resolution HLA sequencing reveals rare immune alleles significantly enriched in patients with Hunner type interstitial cystitis, providing genetic evidence for ...
Rituximab’s Second Act: Rethinking B-Cell Depletion for Lupus Treatment
A new review maps where the off-label anti-CD20 antibody rituximab fits in the treatment of systemic lupus erythematosus, from refractory ...
Antinuclear Antibodies Reveal a Hidden Autoimmune Subtype in a Stubborn Itchy Skin Disease
A retrospective study of 26 Japanese patients finds that roughly one in five cases of prurigo chronica multiformis tests positive ...
Lupus May Quietly Deplete the Ovarian Reserve of Indian Women, Landmark Study Finds
A study of 168 Indian women with lupus found nearly half had a diminished ovarian reserve even without known risk ...
Aging-like B cells emerge as hidden drivers of rheumatoid arthritis onset
Single-cell multiomics reveals that people who progress from ACPA-positive at-risk status to clinical rheumatoid arthritis carry an expansion of senescent-like ...
Oxidative Stress Takes Center Stage in Vitiligo as Scientists Target the Nrf2 Antioxidant Pathway
A new review in the Archives of Dermatological Research positions oxidative stress and the Nrf2 antioxidant pathway at the center ...
T Cells That Recognize the Heart: Mapping the Antigens Behind Cardiac Disease
A new review in Nature Reviews Cardiology lays out a framework for defining heart-specific T cell responses and the cardiac ...
Bacterial Biofilms May Trigger the Autoantibodies Behind Lupus Kidney Damage
New research in mice shows that curli amyloid fibers from Salmonella and E. coli biofilms can drive the production of ...
Scientists Discover Twelve New Autoantibody Signatures Linked to Parkinson’s Disease
A two-stage study of 340 participants in Singapore has identified twelve autoantibodies elevated in Parkinson's disease patients, linked to translation ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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