A Hidden Brain Enzyme Emerges as the Secret Weapon Against Memory Decline in Aging
Scientists have discovered that an aging-induced secreted phospholipase called PLA2G2F acts as a neuron-derived signal that protects synapses, calms inflammatory ...
Tag: astrocytes
The Silent Interval: Hidden Brain Remodeling Precedes the Return of Seizures
A time-resolved study of CYFIP2 Arg87Cys mice reveals that the seizure-free interval in West syndrome is a period of active ...
Intranasal Herpes Virus Remodels Brain Immune Cells in a Region-Specific Pattern
A multiomic study in PLOS Pathogens shows that intranasal HSV-1 infection drives localized, interferon-dominated remodeling of microglia in discrete brainstem ...
A Few Neurons Overexpressing C4 Remodel the Whole Cortical Neighborhood
Overexpressing the schizophrenia-linked complement gene C4 in just two percent of mouse cortical neurons triggers widespread transcriptional, lipid-droplet, and stress ...
Master Switch Discovered That Decides How Adult Spinal Cord Stem Cells Choose Their Fate
New research reveals that the Hippo pathway effector YAP1 acts as a master switch controlling whether adult spinal cord stem ...
Aging Brains Respond Differently in Males and Females, Mouse Study Reveals
A new study in accelerated-aging mice shows that a neurogenesis-boosting compound rescues memory and hippocampal plasticity in males but not ...
Liver and Brain Drive Separate Symptoms in Rare Inherited Epilepsy, Mouse Study Finds
A Johns Hopkins mouse study shows that liver dysfunction drives seizures while astrocyte defects in the brain drive psychiatric symptoms ...
Massive single-nucleus atlas reveals how genetic risk for brain disease acts cell by cell
A single-nucleus atlas of 5.6 million brain cells from 1,384 donors maps cell-type-specific genetic regulation underlying Alzheimer's disease, schizophrenia and ...
Astrocytes Drive the Mitochondrial Traffic Jams Behind a Common Form of ALS
New research shows that astrocytes carrying the C9ORF72 mutation disrupt mitochondrial transport in motor neurons through a contact-dependent bioenergetic mechanism ...
Astrocyte Redox Switch Linked to Synapse Damage in Multiple Sclerosis
A new single-cell and animal study links SLC7A11-high astrocyte states to antioxidant failure and synaptic remodeling in multiple sclerosis, pointing ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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