Rare Facial-Onset Nerve Disease Reveals Its Brain Footprint in Advanced MRI Study
Advanced MRI has revealed the first consistent brain signature of the ultra-rare neurological disorder FOSMN, showing brainstem atrophy and damage ...
Tag: amyotrophic lateral sclerosis
Spinal Fluid Inflammatory Proteins Reveal Why ALS Progresses at Different Speeds
Researchers profiling inflammatory proteins in cerebrospinal fluid have identified a signature, including SIRT2 and MMP-1, that distinguishes slow from fast ...
Molecular Chaperones Keep ALS Protein Droplets From Hardening Into Disease
A new review in BMC Medicine argues that ALS arises when the cellular systems that keep reversible protein condensates from ...
New ALS Classification Reveals That Motor Neuron Type, Not Onset Site, Drives Survival
A population-based study of more than 2,700 ALS patients shows that a new three-axis classification decomposes prognosis, revealing that motor-neuron ...
Broken Cellular Recycling Plants Emerge as Common Thread in Neurodegenerative Disease
A new review in Nature Reviews Neurology argues that defective lysosomal function is a central, genetically validated driver of Parkinson ...
MRI, Genes and Single-Cell Data Point to Vulnerable Brain Regions in ALS
By integrating MRI, brain-wide gene expression and single-cell sequencing, researchers have identified MOBP and ZNHIT3 as candidate genes underlying region-specific ...
Muscle Mass and Sarcopenia Emerge as Powerful Predictors of Survival in ALS
A Spanish cohort study finds that low appendicular skeletal muscle mass and sarcopenia independently predict mortality in ALS, with sarcopenia ...
ALS Protein Clumps Found Far Beyond the Brain Suggest a Whole-Body Disease
A new review finds that the pathological protein TDP-43, the hallmark of ALS, accumulates in muscle, skin, glands and other ...
High-Flow Nasal Cannula Emerges as Lifeline for ALS Patients Who Cannot Tolerate Ventilation Masks
A retrospective case series of 18 ALS patients who could not tolerate non-invasive ventilation suggests that home-based high-flow nasal cannula ...
Human ALS Seeds Transmit Two Distinct SOD1 Aggregation Strains in Mice
Seeds prepared from the spinal cords of ALS patients homozygous for the SOD1 D90A mutation transmitted two distinct strains of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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