MRI, Genes and Single-Cell Data Point to Vulnerable Brain Regions in ALS
By integrating MRI, brain-wide gene expression and single-cell sequencing, researchers have identified MOBP and ZNHIT3 as candidate genes underlying region-specific ...
Tag: amyotrophic lateral sclerosis
Muscle Mass and Sarcopenia Emerge as Powerful Predictors of Survival in ALS
A Spanish cohort study finds that low appendicular skeletal muscle mass and sarcopenia independently predict mortality in ALS, with sarcopenia ...
ALS Protein Clumps Found Far Beyond the Brain Suggest a Whole-Body Disease
A new review finds that the pathological protein TDP-43, the hallmark of ALS, accumulates in muscle, skin, glands and other ...
High-Flow Nasal Cannula Emerges as Lifeline for ALS Patients Who Cannot Tolerate Ventilation Masks
A retrospective case series of 18 ALS patients who could not tolerate non-invasive ventilation suggests that home-based high-flow nasal cannula ...
Human ALS Seeds Transmit Two Distinct SOD1 Aggregation Strains in Mice
Seeds prepared from the spinal cords of ALS patients homozygous for the SOD1 D90A mutation transmitted two distinct strains of ...
Complement Emerges as Central Player and Drug Target in Neurological Disease
A new Nature Reviews Neurology review details how the complement system drives autoimmune and neurodegenerative neurological diseases and how a ...
Motor Neuron Disease Deaths Rise in the US, but Age-Adjusted Rates Hold Steady
A 26-year CDC WONDER analysis of 170,570 US deaths finds motor neuron disease death counts rose 47 percent while age-adjusted ...
Metabolomics reveals muscle cramp and ALS changes with TJ-68 treatment
In the landscape of neurodegenerative disease, amyotrophic lateral sclerosis looms as one of the most unforgiving diagnoses. The disease attacks ...
TDP-43 Loss Triggers Broad Polyadenylation Shifts in FTD/ALS
In a groundbreaking study published in Nature Neuroscience, researchers have unveiled that the nuclear depletion of the protein TDP-43 in ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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