Microglia Move to Center Stage as Alzheimer’s Therapies Enter a New Era
A new review maps how next-generation therapies targeting the brain's resident immune cells could reshape Alzheimer's disease treatment beyond amyloid-centric ...
Tag: Alzheimer’s disease
Higher neuroplasticity marker linked to faster cognitive decline in women only
A six-year study of older adults found that higher cerebrospinal fluid levels of the neuroplasticity marker GAP-43 predicted faster cognitive ...
Sleep loss after brain injury boosts early Alzheimer-like protein changes in mice
A new mouse study shows that traumatic brain injury alone triggers early Alzheimer-like protein variant buildup in wild-type animals, and ...
Gut microbes linked to Alzheimer’s, Parkinson’s, Huntington’s and ALS
A new review links gut microbial imbalances to Alzheimer's, Parkinson's, Huntington's and ALS through inflammation, metabolites and the gut–brain axis.
AI and Omics Converge to Decode the Gene Regulatory Logic of the Brain
A new Brain Informatics review traces how AI methods, from co-expression statistics to causal graph neural networks and foundation models, ...
![Pyrazolo[3,4-b]pyridine emerges as a privileged scaffold in anti-Alzheimer’s drug design](https://scienmag.com/wp-content/uploads/2026/10/stackrss-featured-39980-350x250.png)
Pyrazolo[3,4-b]pyridine emerges as a privileged scaffold in anti-Alzheimer’s drug design
A new review argues that pyrazolopyridine derivatives show therapeutic potential against Alzheimer's disease and distils the structural rules for designing ...
Microglial Activity Patterns Track Tau Buildup in Early Alzheimer’s Disease
A longitudinal PET and fMRI study links two distinct microglial activation signatures, structured by functional brain connectivity, to the spatial ...
Proximity Labeling Maps the Protein Neighborhoods of Two Amyloid Forms in Alzheimer’s Hippocampus
Proximity labeling in postmortem human hippocampus reveals that pyroglutamate-modified Aβ carries an expanded, variant-specific set of neighboring proteins in Alzheimer's ...
Bioelectronic Medicine Summit Charts Neurotechnologies for Patients and Communities
The Sixth Bioelectronic Medicine Summit in New York highlighted bioresorbable implants, gamma-frequency therapy for Alzheimer's disease, vagus nerve advances, and ...
FcRn Blockade Lowers IgG and Alters Amyloid Pathology in Alzheimer’s Model Mice
Blocking the neonatal Fc receptor with efgartigimod reduced circulating IgG and was associated with lower amyloid burden and markers of ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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