Adolescent Oxycodone Exposure Boosts Adult Opioid Self-Administration in Female Mice
A mouse study finds adolescent oxycodone exposure increases adult remifentanil self-administration in females but not males, with sex-specific gene expression ...
Tag: alternative splicing
Exon-Skipping Splicing Changes Distinguish Alzheimer’s Disease from Progressive Supranuclear Palsy
A genomic study of temporal cortex tissue identifies hundreds of exon-skipping events that separate Alzheimer's disease from progressive supranuclear palsy, ...
Study confirms two novel alternatively spliced human RAB8B transcripts
A molecular biology study experimentally confirmed two novel human RAB8B transcripts and used computational models to predict differences in their ...
SRPK1 shows tumour-specific associations with survival and predicted chemotherapy response
A retrospective multi-omics study associated SRPK1 expression with opposite survival patterns and different predicted chemotherapy responses in breast, colon and ...
Gene architecture predicts isoform diversity across four genomes
Longer introns, shorter exons and more complex gene organization were consistently associated with higher transcript-isoform diversity in humans, mice, flies ...
Transcriptomic study links isoform remodeling to survival differences in clear cell renal cell carcinoma
A transcriptomic analysis of 127 ccRCC tumors found 1,170 differentially used transcripts, two expression subgroups with different angiogenic profiles and ...
Mechanical overload elicits weaker transcript isoform switching in aged mouse muscle
Mouse muscle subjected to mechanical overload showed extensive transcript isoform switching in adulthood, but the early response was attenuated in ...
Hidden RNA splice variant drives colorectal cancer spread, study finds
A tumor-specific splice variant of CALD1, driven by the splicing factor hnRNPA1 and acting through the motor protein MYH9, promotes ...
Splice Variants CLDN18.2 and FGFR2b Emerge as Prime Cancer Drug Targets
A new review maps how two splice-variant proteins, CLDN18.2 and FGFR2b, became leading cancer drug targets, and why next-generation antibodies, ...
A Hidden RNA Splice Variant May Predict Relapse After CD19 CAR-T Therapy
Danish researchers report that low-level skipping of CD19 exon 2, detectable in pre-treatment RNA-sequencing data, correlates with relapse after anti-CD19 ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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