TDP-43 Overexpression in Human Cells Reproduces Key ALS Pathology and Gene Changes
Scientists built an inducible human cell line that overproduces TDP-43, triggering toxicity, mislocalization, and gene expression changes that overlap with ...
Tag: alternative splicing
Immune Cells Target Faulty Splicing Neoantigens in Lupus Neutrophils
A study finds that aberrant mRNA splicing in lupus neutrophils produces novel peptides that trigger T cell and autoantibody responses.
Fruit Fly Eggshell Gene Reveals Purifying Selection with Episodes of Positive Evolution
A new study of the defective chorion 1 gene in two major pest fruit flies finds pervasive purifying selection punctuated ...
RNA-Binding Protein VCX3A Drives Spermatogonial Cell Proliferation and Motility Through Splicing Control
A new Cell & Bioscience study shows that the RNA-binding protein VCX3A cooperates with the splicing regulator KHDRBS1 to promote ...
RNA-Binding Protein hnRNPC Drives Cerebellar Growth by Guarding Mtf2 Splicing
A new mouse study shows that the RNA-binding protein hnRNPC supports cerebellar development by suppressing a cryptic exon in Mtf2 ...
Nuclear CK1α joins the WNT transcription machine to drive tumor-initiating cells
Nuclear L-insert-containing CK1α isoforms act as positive components of the β-catenin/TCF complex, while pharmacological CK1α activation with SSTC3 depletes WNT-driven ...
Cutting a Neck Nerve Rewires Gene Networks to Ease Rat Lung Hypertension
In a rat model of pulmonary arterial hypertension, surgically cutting the cervical sympathetic trunk lowered lung pressures and reshaped transcription ...
Adolescent Oxycodone Exposure Boosts Adult Opioid Self-Administration in Female Mice
A mouse study finds adolescent oxycodone exposure increases adult remifentanil self-administration in females but not males, with sex-specific gene expression ...
Exon-Skipping Splicing Changes Distinguish Alzheimer’s Disease from Progressive Supranuclear Palsy
A genomic study of temporal cortex tissue identifies hundreds of exon-skipping events that separate Alzheimer's disease from progressive supranuclear palsy, ...
Study confirms two novel alternatively spliced human RAB8B transcripts
A molecular biology study experimentally confirmed two novel human RAB8B transcripts and used computational models to predict differences in their ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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