Rare Fusion Gene and WT1 Overexpression Define an Aggressive Leukemia Subtype
A newly reported leukemia case carrying both the rare DEK::CAN fusion gene and WT1 overexpression reveals how genetic synergy and ...
Tag: alternative splicing
Blocking the Brain’s Cannabis Receptor Repairs Faulty RNA Splicing in Fragile X Mice
A new study in iScience shows that blocking the cannabinoid CB1 receptor with low-dose rimonabant reverses disease-associated alternative splicing defects ...
Long-Read RNA Sequencing Reveals Hidden Isoform Chaos That Gene-Level Cancer Studies Miss
A long-read RNA sequencing atlas of 144 paired tumor-normal samples across ten organs shows that gene expression changes converge across ...
Fly Study Reveals How the RNA Modifier Mettl16 Shapes Development and Fertility
New research in fruit flies shows that the RNA methyltransferase Mettl16 is dispensable for survival but essential for fertility, acting ...
Hidden RNA switches reshape cancer proteins and sabotage drug targets
A comprehensive multi-omics study catalogues thousands of cancer-specific isoform switches in melanoma, ovarian cancer, and AML, showing that most disrupt ...
RNA-Binding RBM Proteins Emerge as Double-Edged Players in Cancer
A new review in Medical Oncology details how the RBM family of RNA-binding proteins acts as both tumor suppressors and ...
Splicing Factor LUC7L2 Emerges as a Driver of Kidney Damage from Chemotherapy
New research reveals that the RNA splicing factor LUC7L2 drives ferroptotic kidney damage from cisplatin by corrupting the splicing of ...
Hidden RNA Switches May Explain How Eucalyptus Leaves Turn Red Under Stress
A new full-length transcriptome study reveals extensive alternative splicing and identifies three MYB113 genes, including the unusual MYB113c, as regulators ...
Plant RNA Regulation Mapped in Landmark Review for Crop Improvement
A landmark review in SCIENCE CHINA Life Sciences synthesizes decades of research into how diverse RNA molecules regulate plant growth, ...
Splice Variant VEGF165b Emerges as a Natural Shield Against Acute Lung Injury
A newly published study identifies the VEGF-A splice variant VEGF165b as an endogenous protector that shields the lung's blood vessels ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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