Alpha-synuclein seeding more frequent with persistent post-COVID smell loss
A pilot observational study detected alpha-synuclein seeding activity in 35.7% of people with persistent olfactory dysfunction after SARS-CoV-2 infection, compared ...
Tag: alpha-synuclein
Johns Hopkins-led protein-misfolding research protocol receives up to $52.1 million
A Johns Hopkins Medicine-led protocol will use up to $52.1 million in ARPA-H funding to study protein misfolding and develop ...
Landmark Study Reveals How Cellular Recycling Falters in Parkinson’s Disease
A new study reveals that impaired proteasome function, driven by SUMOylation, may underlie the toxic accumulation of alpha-synuclein in Parkinson's ...
Shared Molecular Fingerprint of Alzheimer’s and Lewy Body Dementia Revealed in Human Brain Maps
A whole-transcriptome study of five brain regions from verified Alzheimer's and Lewy body dementia donors reveals a shared molecular signature ...
Brain Waste-Clearing System Linked to Drooling in Parkinson’s Disease, MRI Study Finds
A new MRI study finds that impaired glymphatic clearance, measured by the ALPS index, independently predicts the severity of drooling ...
Six Biological Dimensions May Redefine How MRI Sorts Parkinson’s Disease Patients
A new perspective in npj Parkinson's Disease proposes a six-dimensional MRI-based framework for capturing the biological heterogeneity of Parkinson's disease ...
Mitochondrial protein CHCHD2 emerges as a guardian of the aging brain
New research shows that the age-related decline of the mitochondrial protein CHCHD2 disrupts the mitochondria-lysosome axis and drives proteostatic collapse ...
Paper-Based Sensor Detects Alzheimer’s and Parkinson’s Biomarkers in One Test
Researchers in New Delhi have developed a disposable paper-based electrochemical sensor that simultaneously detects Alzheimer's and Parkinson's disease biomarkers with ...
Brain Immune Cells Nibble Away Parkinson’s Protein Clumps to Shield Vulnerable Neurons
University of Oxford researchers have discovered that a specialised population of human microglia protects dopamine neurons in Parkinson's disease by ...
Hidden Brain Cells Called Oligodendrocytes Emerge as Unexpected Drivers of Parkinson’s Disease
A spatial multi-omics study in Nature Communications identifies disease-associated oligodendrocytes whose interleukin 33–ST2 signaling influences alpha-synuclein burden and motor symptoms ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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