Cholesterol-Tipped Gene Silencers Rescue Failing Neurons in Parkinson’s Mice
A new study shows that cholesterol-conjugated heteroduplex oligonucleotides can silence alpha-synuclein in the mouse brain, protecting dopaminergic neurons through the ...
Tag: alpha-synuclein
Parkinson’s Protein Alpha-Synuclein Drives Clogged Arteries by Jamming Cellular Recycling
New research shows that alpha-synuclein, best known for its role in Parkinson's disease, enters macrophages through the protein FLOT1, blocks ...
Brain Scans Reveal Which Sleep Disorder Patients Will Develop Dementia
A combined PET and MRI imaging signature centred on the posterior cortex can predict which patients with isolated REM sleep ...
Immune Fingerprints in Blood Reveal Parkinson’s Disease When Patients Are Sorted First
By stratifying Parkinson's patients into mouse-model-anchored immune subtypes, researchers have built T-cell receptor blood tests that exceed 0.8 AUC, overturning ...
Blood Test Combo Flags Who Will Develop Parkinson’s Disease Years Early
A new PPMI analysis shows that combining a blood-based microRNA-7-5p measurement with the alpha-synuclein seed amplification assay can identify prodromal ...
Broken Cellular Recycling Plants Emerge as Common Thread in Neurodegenerative Disease
A new review in Nature Reviews Neurology argues that defective lysosomal function is a central, genetically validated driver of Parkinson ...
Immune Receptor FcγRIIb Emerges as Gatekeeper of Parkinson’s Protein Spread
New research shows that deleting or blocking the immune receptor FcγRIIb dramatically impairs the spread of alpha-synuclein pathology in the ...
New PET Tracer Candidate Flags Alpha-Synuclein in Lewy Body Disease But Misses MSA
A new tritium-labeled alpha-synuclein PET ligand, ³H-M503-1619, binds pathological aggregates in postmortem tissue from Lewy body diseases but not in ...
Tiny Biosensors Could Detect Alzheimer’s and Parkinson’s Years Before Symptoms
A comprehensive review shows that miniaturized biosensor platforms can detect Alzheimer's, Parkinson's, and prion disease biomarkers at extraordinary sensitivity, but ...
Scientists Rethink Neuronal Senescence as Brain Aging Markers Fail the Test
A new review argues that neurons can acquire senescence-like states in aging and neurodegenerative disease, but peripheral senescence markers cannot ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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