Brain Scan Fingerprints of Parkinson’s Emerge Years Before Symptoms Appear
A new resting-state fMRI study shows that Parkinson's disease-related brain network patterns can be detected in genetically at-risk people before ...
Tag: alpha-synuclein
Intranasal Rotenone Model Recreates Brain-First Spread of Parkinson’s Pathology in Mice
Researchers have developed a chronic intranasal rotenone mouse model that reproduces the brain-first, olfactory-to-midbrain spread of alpha-synuclein pathology characteristic of ...
Coffee Compound Trigonelline Eases Parkinson’s Symptoms in Mice by Calming Brain Inflammation and Reshaping Gut Microbes
A new preclinical study shows that trigonelline, a coffee-derived alkaloid, reduces alpha-synuclein pathology and neuroinflammation in Parkinson's model mice while ...
Antioxidant Protein Thioredoxin-1 Reshapes Oligodendrocyte Lineage Cells in Parkinson’s Model
A new study shows that the antioxidant protein thioredoxin-1 regulates the expansion of oligodendrocyte lineage cells and the accumulation of ...
How one assay turned prion detection into a revolution across neurodegeneration
A new review in Acta Neuropathologica chronicles how Byron Caughey's development of the RT-QuIC assay revolutionized prion detection and seeded ...
Scientists Watch Proteins at Work Inside Intact Mitochondria Using NMR
Researchers have developed an electroporation-based NMR method that delivers labeled proteins into intact mitochondria, enabling atomic-resolution observation of alpha-synuclein membrane ...
Beyond ALS: Misfolded SOD1 Emerges as a Shared Player in Brain Disease
A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau, ...
Cellular Recycling Pathway Emerges as Central Driver of Ageing and Disease
A new review argues that chaperone-mediated autophagy, the cell's most selective protein degradation pathway, acts as a master regulator of ...
Human GLUD2 Gene Variant Worsens Parkinson’s Disease by Igniting an Astrocyte–Microglia Complement Cascade
A human-specific GLUD2 gene variant worsens Parkinson's disease pathology in mice by driving complement C3 signaling from astrocytes to microglia, ...
Nose-to-Brain Protein Delivery Shows Promise for Protecting Dopamine Neurons in Parkinson’s Models
A new study in BMC Medicine reports that intranasally delivered recombinant BMP2/6 proteins delayed dopaminergic neuron degeneration and improved motor ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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