Chronic Alcohol Disrupts Myelin-Making Brain Cells in Human Cerebellum, Study Finds
A postmortem study of human cerebellar tissue reveals that alcohol use disorder disrupts oligodendrocyte function, insulin/IGF-Akt signaling, and Notch pathway ...
Tag: AKT
Plant-Derived Molecule KGA-1002 Strikes GRP94 to Collapse Liver Cancer’s Protein Folding Machinery
A synthetic guaianolide dimer derived from a plant sesquiterpenoid selectively covalently binds the ER chaperone GRP94 at serine 106, triggering ...
Ancient Herb Compound Purges Zombie Cells That Make Arteries Fragile
Researchers report that salvianolic acid A, a compound from Salvia miltiorrhiza, directly binds HSP90α to dismantle the AKT-PERK survival complex ...
Dual PI3K/mTOR Inhibitor VDC597 Shows Promise Against Canine Lymphoma and Leukemia in Lab Studies
A dual PI3K/mTOR inhibitor, VDC597, suppresses signaling, kills canine lymphoma and leukemia cells in vitro, and synergizes with dexamethasone, according ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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