Physicists Map the Invisible Forces That Fold the Human Genome Inside the Nucleus
A new opinion article explains how phase separation, loop extrusion, and nuclear membrane adsorption together shape the 3D folding of ...
Tag: 3D genome organization
Stronger Chromatin Boundaries Stand the Test of Evolutionary Time
A massive Hi-C study across eight mouse strains shows that the strength of chromatin boundary insulation predicts how faithfully topologically ...
AI Reads the 3D Architecture of Chromatin to Predict Stem Cell Aging
A compact convolutional neural network called ChromAgeNet can distinguish young from aged hematopoietic stem cells using 3D DAPI-stained microscopy images ...
Epigenetic Editing Steps Closer to the Clinic as Bioengineering Tools Mature
The EpiBio-24 conference in Amsterdam showcased maturing epigenetic engineering tools, durable gene silencing in animal models, and growing clinical momentum ...
Open Chromatin Is Not So Open: Active Genes Ride on Condensed Domains
New simulations reveal that euchromatin is mostly condensed into dense domains, with short active regulatory regions protruding on their surfaces ...
Reading the Genome One Molecule at a Time: A Practical Guide to Single-Molecule Genomics
Leading genome researchers have published a practical guide in Nature Reviews Molecular Cell Biology explaining how single-molecule genomics can reveal ...
hnRNPK condensates boost enhancer–promoter looping and RNA polymerase II recruitment
Scientists have identified a molecular organizer that helps connect distant regulatory regions of the genome with the genes they control, ...
Researchers Identify Novel ‘3D Genome Organizer’ Associated with Fertility and Cancer
A groundbreaking discovery by researchers at Kyoto University has unveiled a new player in the intricate world of DNA architecture ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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