It looks like your input was cut off mid-sentence. From what you’ve provided, the passage discusses the challenges in resolving associations between the HLA locus and immune-mediated complex traits, due to factors like allelic diversity, population heterogeneity, and the lack of well-estimated antigens.
Here’s a brief summary of the passage so far:
- The HLA locus is tightly linked to immune-related traits, but understanding the specific associations is difficult.
- The Epstein-Barr Virus (EBV) proteome provides a set of candidate antigens that interact with these HLA alleles.
- Because these alleles variably present EBV antigens, this affects the presence of EBV DNAemia (presence of EBV DNA in blood).
- The researchers assembled four-digit HLA allele data from donors of Non-Finnish European (NFE) or European (EUR) ancestry from UK Biobank (UKB) and All of Us (AOU) cohorts.
- They performed multivariate regression to find associations between HLA alleles and EBV DNAemia.
- They identified 42 associated HLA alleles in total (18 class I and 24 class II alleles) with a nominal P-value threshold (not fully detailed due to cutoff).
If you provide the rest of the text or your specific questions about this, I could assist further! Would you like me to help interpret this study further, summarize more, or analyze particular parts?
