A groundbreaking study published in the esteemed journal Aging (Aging-US) sheds new light on the potential for a natural, multi-ingredient supplement regimen to mitigate biological aging and enhance physical health in older adults. The clinical investigation focuses on the Cel System, a compound formulation designed to target the fundamental mechanisms known as the Hallmarks of Aging, an influential framework describing the molecular and cellular causes underlying the progressive decline associated with aging. Over a 12-month period, this single-arm clinical trial reports compelling evidence of slowed epigenetic aging alongside measurable improvements in physical function and body composition in a diverse pool of middle-aged to elderly participants.
The Cel System supplement is a blend of plant-derived compounds, vitamins, and antioxidants meticulously selected for their purported synergistic effects on pathways integral to aging biology. The rationale behind this proprietary mixture stems from emerging research pinpointing molecular drivers such as genomic instability, mitochondrial dysfunction, and altered intercellular communication as modifiable targets. By influencing these critical nodes, the supplement aims to attenuate the cascade of detrimental changes that culminate in frailty and age-related diseases.
The study cohort comprised 51 adults aged between 54 and 84 years, evenly split between men and women, who committed to daily supplementation with the three-part Cel System — denoted as Cel1, Cel2, and Cel3 — formulated to work in concert. Participants also engaged in modest lifestyle adjustments, including brief periods of walking and mindfulness exercises, intended to complement the supplement’s physiological effects. The research team, led by experts from TruDiagnostic, utilized cutting-edge DNA methylation-based epigenetic clocks to quantify biological age changes, bridging the gap between subjective health measures and molecular aging markers.
Results from the trial revealed significant enhancements in physical performance metrics. Grip strength, a reliable predictor of morbidity and mortality, increased steadily over time, suggesting improved muscular resilience. Lower body mobility, assessed through chair-stand and one-leg stand tests, also saw statistically meaningful gains. Alongside these functional improvements, participants exhibited reductions in standard anthropometric measures such as body weight, waist circumference, and body mass index, indicating favorable shifts in body composition consistent with healthier aging phenotypes.
At the molecular level, epigenetic analysis demonstrated a deceleration of biological aging as captured by several validated methylation clocks. These clocks integrate patterns of DNA methylation at numerous genomic sites to estimate an individual’s biological rather than chronological age. The observed retardation in epigenetic age implies that the supplement may modulate gene regulatory networks that dictate cellular senescence and renewal, ultimately influencing systemic aging processes.
Particularly noteworthy was the observed decrease in stem cell turnover rates, a finding with profound implications. Stem cells serve as the body’s regenerative reservoir, and their depletion or dysfunction represents a hallmark of aging that contributes to tissue degeneration. By preserving stem cell viability and reducing excessive turnover, the supplement may help sustain regenerative capacity and delay the onset of age-related degenerative conditions.
Immune system remodeling also proved evident, with shifts in immune cell composition tracked over the course of the trial. Aging is frequently accompanied by immunosenescence — a decline in immune function that increases susceptibility to infections and chronic inflammation. Although traditional inflammatory markers remained unchanged, the modulation of immune cell subsets points toward an intricate regulatory effect that could enhance immune surveillance without provoking systemic inflammation.
Further molecular insights emerged from analyses of DNA methylation changes in genes tied to stress response, neuronal function, and intercellular communication. These epigenetic alterations point to the supplement’s capacity to influence pathways critical for maintaining cellular homeostasis and cognitive health. The data suggest potential neuroprotective benefits, a pivotal consideration given the burden of neurodegenerative diseases in aging populations.
While the study lacked a randomized control group — limiting definitive causal inference — the comprehensive data set amalgamating epigenetic, physiological, and biochemical measures substantiates the Cel System’s promise as a multi-targeted anti-aging intervention. The research team advocates for expanded trials with larger cohorts and placebo controls to validate and extend these findings, as well as to explore the supplement’s impact on lifespan and healthspan parameters.
This trial represents a significant stride in translational geroscience, demonstrating the feasibility of leveraging naturally derived nutraceuticals to modify biological aging markers. By integrating epigenetic clock assessments with functional health endpoints, the study exemplifies a paradigm shift toward precision interventions that address aging at its root causes rather than merely treating symptoms.
The implication of these findings resonates beyond academic research, holding potential for public health strategies aimed at fostering resilience and extending quality of life during aging. As interest surges in the development of safe, accessible, and effective longevity therapeutics, the Cel System emerges as a promising candidate warranting further scientific scrutiny and clinical validation.
In sum, this pioneering clinical trial provides robust evidence that targeted natural supplements can slow epigenetic aging, enhance physical performance, and positively modulate body composition in older adults. By addressing the multifactorial nature of aging through a systems biology approach, the Cel System supplement range may pave the way for next-generation therapeutics tailored to promote healthy aging trajectories and mitigate age-related decline.
Subject of Research: People
Article Title: Effects of a natural ingredients-based intervention targeting the hallmarks of aging on epigenetic clocks, physical function, and body composition: a single-arm clinical trial
News Publication Date: 14-Mar-2025
Web References:
https://dx.doi.org/10.18632/aging.206221
https://www.aging-us.com/issue/v17i3
Image Credits: Copyright: © 2025 Carreras-Gallo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0).
Keywords: aging, epigenetic age change, physiological age change, epigenetic biomarker proxies, hallmarks of aging, nutraceutical longevity interventions
