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Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy

July 30, 2026
in Biology
Morgan Morrow
By Morgan Morrow Scienmag Editorial Profile - Bacteriology
Reading Time: 1 min read
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Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy

Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy

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Kramer, D., Santos Rocha, C., Gaulke, C.A. et al. Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy.
Nat Microbiol 11, 2365–2383 (2026). https://doi.org/10.1038/s41564-026-02433-0

August 2026

Subject of Research: Biology

Article Title: Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy

Article References: Kramer, D., Santos Rocha, C., Gaulke, C. A., Nearing, M., Sankaran-Walters, S., Loque, I., Kidigannappa, A., Pham, E., Hu, S., Wanakumjorn, P., Abbattista, R., Dandekar, A., Faller, R., & Dandekar, S. (2026). Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy. Nature Microbiology, 11(8), 2365-2383. https://doi.org/10.1038/s41564-026-02433-0

Image Credits: AI Generated

DOI: 10.1038/s41564-026-02433-0

Keywords: Not provided

Cite Scienmag News

Morgan Morrow. (July 30, 2026). Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy. Scienmag. https://scienmag.com/microbiota-derived-10-hydroxystearic-acid-activates-ppar%ce%b1-to-restore-gut-epithelial-barrier-integrity-and-enhance-anti-retroviral-therapy/

Morgan Morrow. "Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy." Scienmag, 30 July 2026, https://scienmag.com/microbiota-derived-10-hydroxystearic-acid-activates-ppar%ce%b1-to-restore-gut-epithelial-barrier-integrity-and-enhance-anti-retroviral-therapy/. Accessed 4 September 2026.

Morgan Morrow. "Microbiota-derived 10-hydroxystearic acid activates PPARα to restore gut epithelial barrier integrity and enhance anti-retroviral therapy." Scienmag. July 30, 2026. https://scienmag.com/microbiota-derived-10-hydroxystearic-acid-activates-ppar%ce%b1-to-restore-gut-epithelial-barrier-integrity-and-enhance-anti-retroviral-therapy/

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