Ivonescimab plus chemotherapy in non–small cell lung cancer with EGFR variant

About The Study: Ivonescimab plus chemotherapy significantly improved progression-free survival with tolerable safety profile in patients with non–small cell lung cancer who previously underwent EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment and may offer a new treatment option for patients with TKI resistance. 

Quote from corresponding author Li Zhang, M.D.:

“For patients with non-small cell lung cancer whose illness has progressed while receiving EGFR tyrosine kinase inhibitor (EGFR-TKI) therapy, especially the third generation TKIs, optimal treatment options remain limited.

“This randomized, placebo-controlled phase 3 study demonstrated ivonescimab plus chemotherapy significantly improved progression-free survival (7.1 vs 4.8 months) compared with chemotherapy alone in TKI-treated non-small cell lung cancer.

“Based on the results of this study, ivonescimab has been approved in China as a new treatment option for those patients. An international multi-center study of this treatment regimen is ongoing.”

Contact information for Li Zhang, M.D.: email zhangli@sysucc.org.cn.

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(doi:10.1001/jama.2024.10613)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Media advisory: This study is being presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting.

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