Medicine
Retuning Synaptic Dynamics Restores Memory Signals in Alzheimer’s Model
A computational model of Alzheimer's disease shows that adjusting short-term synaptic facilitation time constants can restore memory engram selectivity and...
Large dogs die young and dog mortality mirrors human death patterns across states
An analysis of 41,047 dogs in the Dog Aging Project finds that body size most strongly predicts canine lifespan, while...
Research report: Sonic hedgehog-matrix metalloproteinase crosstalk in neurovascular ageing and stroke: a potential mechanistic link
A GeroScience review proposes that an age-related imbalance between protective Sonic hedgehog signalling and degradative MMP activity may link neurovascular...
Fermented Gallnut Extract Shows Mitochondrial Boost in UV-Damaged Skin Cells in Lab Study
A laboratory study found that a Lactiplantibacillus plantarum-fermented Galla rhois gallnut extract improved mitochondrial respiratory markers in UV-damaged human dermal...
Internalized Stigma Independently Predicts Depression in Adolescents with Acne
A prospective case–control study of 154 adolescents found that internalized stigma independently predicted major depression in patients with acne vulgaris,...
Engineered T-BET Pushes Lab-Grown NK Cells Toward Inflammation, Not Full Maturity
Forcing T-BET expression in iPSC-derived NK cells boosted IFN gamma and inflammatory chemokines but left cytotoxic function and terminal maturation...
Gut Dysbiosis Linked to Chronic Endometritis Remains a Hypothesis, Review Finds
A structured narrative review finds no direct human evidence linking gut dysbiosis to histologically confirmed chronic endometritis, framing the proposed...
Stress-triggered mitochondrial protein aggregates relay quality-control signals to the ER
Researchers report that stressed mitochondria form protein aggregates called SIMPAs that signal through GRP75 at mitochondria–ER contact sites to trigger...
Frontiers Retracts Corrigendum on ABTL0812 in Glioblastoma Over Image Concerns
Frontiers in Oncology has retracted a 2025 corrigendum on the anticancer effects of ABTL0812 in glioblastoma models after the authors...
Obesity May Harm Sperm Motility Through a STAT3/MTND4 Mitochondrial Pathway in Mice
A mouse and cell study reports that STAT3 transcriptionally activates MTND4, driving ROS production and mitochondrial dysfunction linked to obesity-related...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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