Medicine
Simulated Patients Replace Human Trials in Virtual Test of Roxithromycin Drug Equivalence
Chinese researchers validated a physiologically based pharmacokinetic model of roxithromycin and used it to run a virtual bioequivalence trial in...
Deadly Fungal Eye Infection Strikes Healthy Greenhouse Worker, Doctors Warn
A 30-year-old Iranian greenhouse worker with no immune deficits lost his eye socket to invasive Rhizopus infection, highlighting occupational mold...
Blood Tests That Read the Brain: A Roadmap for Molecular Biomarkers in Stroke Care
A new Nature Reviews Neurology roadmap charts how blood-based molecular biomarkers of brain injury, metabolism, inflammation and gut dysbiosis could...
Prostate Cancer Drug Enzalutamide Extends Lives but Fails the Cost-Effectiveness Test at Current Prices
A within-trial economic analysis of the ENZAMET phase 3 trial finds that enzalutamide significantly extends survival in metastatic hormone-sensitive prostate...
Antidepressants and Breast Cancer: Landmark Analysis of Nearly Two Million Women Reveals Timing Matters
A meta-analysis of twenty-three studies covering nearly 1.83 million women finds that short-term SSRI use is associated with a modest...
Mouse Models Show Teeth Can Expose Hidden Signs of Rare Bone Disease
New knock-in mouse models of hypophosphatasia show that specific ALPL gene variants shape dental symptoms independently of blood enzyme levels,...
The Dark Side of Good Cholesterol: Rogue HDL Particle Drives Arterial Aging
Scientists have identified an electronegative HDL subfraction enriched in apolipoprotein(a) that induces endothelial senescence through the p53–p21 pathway and accelerates...
How Gravity Sculpts Crops: New Insights Could Reshape Maize Breeding
A comprehensive review maps the molecular machinery of plant gravitropism and predicts 69 candidate genes that could let breeders engineer...
Chemical Tag on mRNA Emerges as Master Switch Behind Tumor Immune Evasion
A new review in the Journal of Translational Medicine details how the m6A RNA modification acts as a bidirectional switch...
Beyond ALS: Misfolded SOD1 Emerges as a Shared Player in Brain Disease
A sweeping review of human neuropathological evidence shows that misfolded SOD1, long tied to familial ALS, coexists with TDP-43, tau,...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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