In vitro screening identifies plant products with strongest acetylcholinesterase inhibition
An in vitro screening of 18 plant products identified four essential oils and one methanolic extract with the strongest acetylcholinesterase...
ABCA1 cholesterol trafficking implicated in Parkinson’s neurodegeneration in mice
Human postmortem tissue, cultured cells and mouse experiments implicated abnormal ABCA1-dependent cholesterol trafficking in Parkinson’s-related neurodegeneration.
Home-cage testing finds early memory deficits in Alzheimer’s mouse model
An automated home-cage platform detected working-memory deficits and subtle prefrontal synaptic changes in a familial Alzheimer’s disease mouse model at...
Theobromine Shows Parkinson’s Promise, but Human Evidence Remains Thin
Biochemical and animal studies suggest that cocoa-derived theobromine can affect monoamine oxidase, adenosine and neuronal signaling, but no clinical evidence...
Integrated computational screening and biochemical validation identify natural small molecules targeting Aβ aggregation and dissociation
A computational screen followed by cell-free Aβ42 assays identified four Jowiseungchungtang-derived small molecules that inhibited aggregation, with two also reducing...
Cyanidin glycosides protect zebrafish brains in Alzheimer’s-like model
Three food-derived cyanidin glycosides protected adult zebrafish in an aluminum-induced Alzheimer’s-like model, with cyanidin-3-O-rutinoside showing the strongest overall effects on...
What You Eat Could Decide How Well Parkinson’s Drugs Work
A new review in Frontiers in Nutrition reveals how dietary protein, meal timing, and gut bacteria competitively hijack levodopa transport...
Why Some Neurons Break While Others Bend: Redox Thresholds Hold the Answer
For decades, neuroscientists have wrestled with one of the most puzzling contrasts in biology: why neurons in the central nervous...
Two Blood Proteins Could Let Doctors Stage Alzheimer’s Disease With a Simple Draw
A new Nature Communications study shows that plasma eMTBR-tau243 and p-tau205 rise during the later tau aggregation stage of Alzheimer's...
Finger-prick blood test for Alzheimer’s biomarkers works for some proteins but fails on pTau217
A Johns Hopkins study of 192 patients shows two FDA-cleared capillary blood collection devices reliably measure NfL, GFAP and Aβ42/40...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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