Monday, September 29, 2025
Science
No Result
View All Result
  • Login
  • HOME
  • SCIENCE NEWS
  • CONTACT US
  • HOME
  • SCIENCE NEWS
  • CONTACT US
No Result
View All Result
Scienmag
No Result
View All Result
Home Science News Cancer

Age-associated gene expression changes in mouse sweat glands

May 14, 2024
in Cancer
Reading Time: 5 mins read
0
Figure 5
66
SHARES
602
VIEWS
Share on FacebookShare on Twitter
ADVERTISEMENT

“In this study, we first obtained evidence that, in mouse, aging primarily reduced the number of active sweat glands.”

Figure 5

Credit: 2024 Zonnefeld et al.

“In this study, we first obtained evidence that, in mouse, aging primarily reduced the number of active sweat glands.”

BUFFALO, NY- May 14, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science) Volume 16, Issue 8, entitled, “Characterization of age-associated gene expression changes in mouse sweat glands.”

Evaporation of sweat on the skin surface is the major mechanism for dissipating heat in humans. The secretory capacity of sweat glands (SWGs) declines during aging, leading to heat intolerance in the elderly, but the mechanisms responsible for this decline are poorly understood. In this new study, researchers Alexandra G. Zonnefeld, Chang-Yi Cui, Dimitrios Tsitsipatis, Yulan Piao, Jinshui Fan, Krystyna Mazan-Mamczarz, Yutong Xue, Fred E. Indig, Supriyo De, and Myriam Gorospe from the National Institutes of Health’s National Institute on Aging investigated the molecular changes accompanying SWG aging in mice, where sweat tests confirmed a significant reduction of active SWGs in old mice relative to young mice. 

“We first identified SWG-enriched mRNAs by comparing the skin transcriptome of Eda mutant Tabby male mice, which lack SWGs, with that of wild-type control mice by RNA-sequencing analysis.”

This comparison revealed 171 mRNAs enriched in SWGs, including 47 mRNAs encoding ‘core secretory’ proteins such as transcription factors, ion channels, ion transporters, and trans-synaptic signaling proteins. Among these, 28 SWG-enriched mRNAs showed significantly altered abundance in the aged male footpad skin, and 11 of them, including Foxa1, Best2, Chrm3, and Foxc1 mRNAs, were found in the ‘core secretory’ category. Consistent with the changes in mRNA expression levels, immunohistology revealed that higher numbers of secretory cells from old SWGs express the transcription factor FOXC1, the protein product of Foxc1 mRNA. 

“In sum, our study identified mRNAs enriched in SWGs, including those that encode core secretory proteins, and altered abundance of these mRNAs and proteins with aging in mouse SWGs.”
 

Read the full paper: DOI: https://doi.org/10.18632/aging.205776 

Corresponding Authors: Chang-Yi Cui, Myriam Gorospe

Corresponding Emails: cuic@mail.nih.gov, gorospem@grc.nia.nih.gov 

Keywords: FOXA1, BEST2, FOXC1, ectodysplasin/Eda, Tabby

Go Behind the Study with the author interview.

Click here to sign up for free Altmetric alerts about this article.

 

About Aging:

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

Please visit our website at www.Aging-US.com​​ and connect with us:

  • Facebook
  • X, formerly Twitter
  • Instagram
  • YouTube
  • LinkedIn
  • Reddit
  • Pinterest
  • Spotify, and available wherever you listen to podcasts

 

Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

 

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

###



Journal

Aging-US

DOI

10.18632/aging.205776

Method of Research

Observational study

Subject of Research

Animals

Article Title

Characterization of age-associated gene expression changes in mouse sweat glands

Article Publication Date

17-Apr-2024

Share26Tweet17
Previous Post

Lessons in chemistry: Guo aims at fundamental understanding of emerging semiconductor material

Next Post

MIT researchers discover the universe’s oldest stars in our own galactic backyard

Related Posts

blank
Cancer

Distinct and Shared Roles of RECQL4, BLM Helicases in Glioma Response

September 29, 2025
blank
Cancer

Calcification: Key Indicator of Lung Metastasis in Osteosarcoma

September 29, 2025
blank
Cancer

AI Enables Real-Time Differentiation of Glioblastoma from Similar Tumors During Surgery

September 29, 2025
blank
Cancer

Ezetimibe Reduces Long-term Cancer Risk: Nationwide Study

September 29, 2025
blank
Cancer

New Simple Test Accurately Predicts Risk of Severe Liver Disease

September 29, 2025
blank
Cancer

ASTRO: Innovative Therapy Slows Progression of Recurrent Prostate Cancer

September 28, 2025
Next Post
Oldest Stars

MIT researchers discover the universe’s oldest stars in our own galactic backyard

  • Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study

    27560 shares
    Share 11021 Tweet 6888
  • University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept

    969 shares
    Share 388 Tweet 242
  • Bee body mass, pathogens and local climate influence heat tolerance

    646 shares
    Share 258 Tweet 162
  • Researchers record first-ever images and data of a shark experiencing a boat strike

    512 shares
    Share 205 Tweet 128
  • Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function

    472 shares
    Share 189 Tweet 118
Science

Embark on a thrilling journey of discovery with Scienmag.com—your ultimate source for cutting-edge breakthroughs. Immerse yourself in a world where curiosity knows no limits and tomorrow’s possibilities become today’s reality!

RECENT NEWS

  • Cognitive Behavioral Therapy in Japan: Insurance Data Analysis
  • Dynamical Dark Energy Refined by DESI DR2 Data
  • Uncertainty-Aware Models Distinguish Glioblastoma from Mimics
  • Analyzing Supply-Demand Dynamics in China’s Childcare Policies

Categories

  • Agriculture
  • Anthropology
  • Archaeology
  • Athmospheric
  • Biology
  • Blog
  • Bussines
  • Cancer
  • Chemistry
  • Climate
  • Earth Science
  • Marine
  • Mathematics
  • Medicine
  • Pediatry
  • Policy
  • Psychology & Psychiatry
  • Science Education
  • Social Science
  • Space
  • Technology and Engineering

Subscribe to Blog via Email

Enter your email address to subscribe to this blog and receive notifications of new posts by email.

Join 5,184 other subscribers

© 2025 Scienmag - Science Magazine

Welcome Back!

Login to your account below

Forgotten Password?

Retrieve your password

Please enter your username or email address to reset your password.

Log In
No Result
View All Result
  • HOME
  • SCIENCE NEWS
  • CONTACT US

© 2025 Scienmag - Science Magazine

Discover more from Science

Subscribe now to keep reading and get access to the full archive.

Continue reading