Human TOM and TIM22 complexes join forces to import mitochondrial carriers

Subject of Research: Biology

Article Title: Human TOM and TIM22 complexes join forces to import mitochondrial carriers

Article References: Liu, X., Cai, H., Wang, H., Zhou, X., Zhang, Y., Liu, S., Zhu, J., & Li, L. (2026). Direct coupling of human TOM and TIM22 complexes drives mitochondrial carrier import. Nature Structural & Molecular Biology, 33(8), 1224-1235. https://doi.org/10.1038/s41594-026-01849-w

Image Credits: AI Generated

DOI: 10.1038/s41594-026-01849-w

Keywords: cellular energy metabolism, human mitochondrial protein import mechanisms, mitochondrial biogenesis, mitochondrial carrier assembly, mitochondrial carrier protein import, mitochondrial function and dynamics, mitochondrial import machinery, mitochondrial membrane protein import, molecular cooperation in mitochondria, protein translocases in mitochondria, TIM22 complex mitochondrial insertion, TOM complex mitochondrial translocation