Vitamin-Derived Molecule Shows First Signs of Treating Mitochondrial DNA Disease in Humans
A four-week trial of nicotinamide riboside in eight patients with mitochondrial DNA disease shows the first human evidence of molecular ...
Tag: mitochondrial biogenesis
Protein Fragment From Thrombospondin-1 Emerges as Exercise-Powered Booster of Muscle and Metabolism
A study in Experimental & Molecular Medicine shows that the N-terminal fragment of thrombospondin-1 enhances muscle function and drives tissue-specific ...
One Amino Acid Decides Whether Mitochondria Keep Their Protein Machines Intact
A single N-terminal amino acid removed during mitochondrial protein maturation globally stabilizes the organelle's protein complexes, revealing a new layer ...
Plant Compound Syringaresinol Fires Up Muscle Hormone Irisin to Fight Weight Gain
New research shows the plant lignan syringaresinol activates the skeletal muscle SIRT1–PGC-1α–FNDC5/irisin axis in cells and high-fat-diet-fed mice, reducing weight ...
Regulating PGC-1α: interactions, modifications, and drug targeting approaches
The master metabolic conductor PGC-1α, long recognized as the central transcriptional coactivator governing cellular energy metabolism across heart, skeletal muscle, ...
Human TOM and TIM22 complexes join forces to import mitochondrial carriers
For the first time, scientists have captured the human machinery that imports metabolite carriers into mitochondria in the act of ...
Neural stem cell exosomes activate HMGB1/TLR2 signaling, boosting astrocyte repair after radiation
A new study in Cell Death Discovery reports that exosomes released by neural stem cells can orchestrate a molecular chain ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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