University of Maryland study shows N95 masks near-perfect at blocking escape of airborne COVID-19

COLLEGE PARK, Md. – In a head-to-head comparison of masks worn by people with active
COVID-19, the inexpensive “duckbill” N95 came out on top, stopping 98% of COVID-19 particles
in the breath of infected people from escaping into the air. Led by researchers from the University
of Maryland School of Public Health (SPH), results showed other masks also performed well,
blocking at least 70% of viral particles from escaping from the source – an infected person’s
exhaled breath.

The study, Relative efficacy of masks and respirators as source control for viral aerosol shedding
from people infected with SARS-CoV-2, published May 29 in eBioMedicine, a Lancet journal.

“The research shows that any mask is much better than no mask, and an N95 is significantly
better than the other options. That’s the number one message,” says the study’s senior author,
Dr. Donald Milton. Milton is a UMD SPH professor of environmental health and a global expert on
how viruses spread through the air.

The study started in May 2020, shortly after the pandemic began, and compared breath samples
from volunteers who had active COVID-19, testing the performance of four commonly-used
masks. Even without giving participants fit tests or training on how to wear masks correctly, all
masks significantly reduced the amount of virus escaping into the air. The study tested masks as
a way to control the spread of the virus from the source, i.e. the infected person, and did not test
masks as protection from COVID-19 in the surrounding air.

“Because COVID-19 is airborne, we focused on the extent to which wearing a mask reduces
contamination of the air around you,” Milton says. This latest study is a continuation of
investigations by UMD’s Public Health AeroBiology Lab (PHAB Lab) into how contagious
respiratory viruses such as influenza contaminate the air.

Researchers asked volunteers with COVID-19 to breathe into a unique contraption known as the
Gesundheit II Machine, developed by Milton and colleagues to measure viruses in exhaled
breath. Participants, who breathed into the machine for 30 minutes at a time, were asked to do a
variety of vocalizations such as repeating the alphabet, singing Happy Birthday, and even
honoring UMD’s mascot by repeatedly shouting “Go Terps!”

In each instance, researchers measured the amount of viral particles in the exhaled breath of
volunteers, pairing each 30-minute session of breathing with a mask on with another 30-minute
session with no mask.

“Data from our study suggests that a mildly symptomatic person with COVID-19 who is not
wearing a mask exhales a little over two infectious doses per hour,” says first author Dr. Jianyu
Lai, a postdoctoral researcher at the PHAB Lab. “But when wearing an N95 mask, the risk goes
down exponentially.”

The duckbill N95 blocked 99% of large particles and 98% of small particles from escaping out of
a person’s mask. Milton says the design’s tight seal, a powerful filter, and large air space for
breath to move around all contribute to the duckbill’s success.

Surprisingly, KN95 masks – the disposable masks used widely – were no more effective than
cloth or surgical masks. The study found that a common brand of KN95 masks leak more air than
duckbills or other studied masks, because they don’t conform to the face well. That flaw is
compounded by a powerful filter with more flow resistance that pushes air out of the mask at the
sides instead of through the filter, allowing more virus particles to escape into the surrounding air.

Cloth masks also outperformed both KN95 and surgical masks. Milton theorizes that cloth masks
with greater coverage, wrap around the face and give a better seal than either KN95 or surgical
masks. With cloth mask filters, flow resistance is also lower, allowing breath to pass through the
filter and not leak out the sides of the mask.

Limiting the amount of viral particles in the air is a key way to control highly contagious
respiratory viruses in general, Milton said. This is even more the case with the COVID-19 virus,
given transmissibility has increased over time, with Omicron in particular breaking through the
immunity people developed from vaccinations or prior infections.

“Our research shows definitively why it’s so important to have non-pharmaceutical responses like
wearing masks, and why we need studies like this to illuminate which masks are most effective,”
says Milton.

Both Milton and Lai hope that their findings will inform health policies going forward, including
when combatting potential outbreaks like bird flu or even the common flu.

“Duckbill N95 masks should be the standard of care in high-risk situations, such as nursing
homes and health care settings,” Lai says. “Now, when the next outbreak of a severe respiratory
virus occurs, we know exactly how to help control the spread, with this simple and inexpensive
solution.”

In addition to researchers from the UMD School of Public Health, collaborators include authors
from the UMD A. James Clark School of Engineering and the World Health Organization
Collaborating Centre for Infectious Disease Epidemiology and Control at the University of Hong
Kong, China.

This research was supported by the Prometheus-UMD, sponsored by the Defence Advanced
Research Projects Agency (agreement N66001-18-2-4015), the National Institute of Allergy and
Infectious Diseases Centers of Excellence for Influenza Research and Surveillance (contract
12-HHSN272201400008C), and the Centers for Disease Control and Prevention (contract
200-2020-09528); by a grant from the Bill & Melinda Gates Foundation; and by a gift from The
Flu Lab.

##