BUFFALO, NY- August 6, 2024 – On July 28, 2024, Mikhail V. Blagosklonny M.D., Ph.D., from Roswell Park Comprehensive Cancer Center published a new editorial in Volume 16, Issue 14 of Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science), entitled, “Targeted cancer therapy: the initial high concentration may slow down the selection for resistance.”
Credit: 2024 Blagosklonny et al.
BUFFALO, NY- August 6, 2024 – On July 28, 2024, Mikhail V. Blagosklonny M.D., Ph.D., from Roswell Park Comprehensive Cancer Center published a new editorial in Volume 16, Issue 14 of Aging (listed by MEDLINE/PubMed as “Aging (Albany NY)” and “Aging-US” by Web of Science), entitled, “Targeted cancer therapy: the initial high concentration may slow down the selection for resistance.”
“Unfortunately, any targeted therapy is, always, started with low levels of the drug in the organism, selecting for drug resistance. One should propose that initial drug levels must be maximized, and durations may be minimized, ideally, as portions of preemptive combination of targeted drugs.”
Corresponding Author: Mikhail V. Blagosklonny – Blagosklonny@oncotarget.com, Blagosklonny@rapalogs.com
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Journal
Aging-US
Method of Research
Commentary/editorial
Subject of Research
Not applicable
Article Title
Targeted cancer therapy: the initial high concentration may slow down the selection for resistance
Article Publication Date
28-Jul-2024
COI Statement
The author declares no conflicts of interest related to this study.
Cite Scienmag News
Nathaniel Bowman. (August 6, 2024). Targeted cancer therapy: initial high concentration may slow down selection for resistance. Scienmag. https://scienmag.com/targeted-cancer-therapy-initial-high-concentration-may-slow-down-selection-for-resistance/
Nathaniel Bowman. "Targeted cancer therapy: initial high concentration may slow down selection for resistance." Scienmag, 6 August 2024, https://scienmag.com/targeted-cancer-therapy-initial-high-concentration-may-slow-down-selection-for-resistance/. Accessed 6 September 2026.
Nathaniel Bowman. "Targeted cancer therapy: initial high concentration may slow down selection for resistance." Scienmag. August 6, 2024. https://scienmag.com/targeted-cancer-therapy-initial-high-concentration-may-slow-down-selection-for-resistance/
