First-in-human trial of TEAD inhibitor BPI-460372 shows early signals and safety limits
A first-in-human phase Ia trial reports that the covalent TEAD palmitoylation inhibitor BPI-460372 showed preliminary antitumor activity in advanced solid ...
Tag: YAP/TAZ
Phase-Separating Condensates Emerge as Drivers of Glioblastoma Progression and Drug Resistance
A review in Acta Neuropathologica Communications describes how aberrant liquid-liquid phase separation may drive glioblastoma progression and therapy resistance, and ...
Scientists propose a two-layer signaling map to guide ovarian reserve therapies
A new review proposes a two-layer signaling network organizing female germline stem cell fate as a testable framework for staged ...
Scientists pinpoint THBS1 as a driver of fat tissue scarring in obesity and diabetes
A single-nucleus atlas of human visceral fat identifies THBS1-expressing stem cells and adipocytes as drivers of fibro-inflammatory remodeling in obesity ...
Ancient Growth-Control Pathway Emerges as a Master Switch of Brain Ageing
A new review in Biogerontology argues that the Hippo–YAP/TAZ signalling pathway acts as a central hub linking brain ageing, neurodegeneration, ...
Stiff Tissue, Sick Tissue: How Mechanics May Drive Endometriosis and Adenomyosis
A new review in Reproductive Sciences proposes that tissue stiffness and mechanotransduction pathways may help explain the heterogeneity and progression ...
How Tumor Stiffness May Rewire RNA Chemistry to Help Cancers Evade Immunity
A new review in Molecular Cancer proposes that mechanical forces within tumors can reprogram RNA modifications, offering a fresh framework ...
Blood Vessel Protein Epac1 Found to Fuel Melanoma Growth Through YAP/TAZ Signalling
New research shows that the endothelial protein Epac1 drives melanoma growth and angiogenesis by coordinating VEGFR2 signalling, RhoA-dependent cytoskeletal dynamics, ...
SOX9 Acts Early to Rewire Hippo–YAP/TAZ Signaling as Glioblastoma Cells Turn Stem-Like
New research shows that the transcription factor SOX9 primes Hippo–YAP/TAZ pathway rewiring during a narrow early window of stemness acquisition ...
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Mothers who receive childcare support from maternal grandparents show more parental warmth, finds NTU Singapore study
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University of Seville Breaks 120-Year-Old Mystery, Revises a Key Einstein Concept
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Bee body mass, pathogens and local climate influence heat tolerance
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Researchers record first-ever images and data of a shark experiencing a boat strike
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Groundbreaking Clinical Trial Reveals Lubiprostone Enhances Kidney Function
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